- SLC7A11
Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11, also known as SLC7A11, is a human
gene .cite web | title = Entrez Gene: SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23657| accessdate = ]PBB_Summary
section_title =
summary_text = SLC7A11 is a member of a heteromeric Na(+)-independent anionic amino acid transport system highly specific for cystine and glutamate. In this system, designated system Xc(-), the anionic form of cystine is transported in exchange for glutamate. [supplied by OMIM] cite web | title = Entrez Gene: SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23657| accessdate = ]ee also
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Solute carrier family References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Sato H, Tamba M, Ishii T, Bannai S |title=Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11455–8 |year= 1999 |pmid= 10206947 |doi=
*cite journal | author=Bridges CC, Kekuda R, Wang H, "et al." |title=Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells. |journal=Invest. Ophthalmol. Vis. Sci. |volume=42 |issue= 1 |pages= 47–54 |year= 2001 |pmid= 11133847 |doi=
*cite journal | author=Sato H, Tamba M, Kuriyama-Matsumura K, "et al." |title=Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-. |journal=Antioxid. Redox Signal. |volume=2 |issue= 4 |pages= 665–71 |year= 2001 |pmid= 11213471 |doi=
*cite journal | author=Shih AY, Murphy TH |title=xCt cystine transporter expression in HEK293 cells: pharmacology and localization. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 5 |pages= 1132–7 |year= 2001 |pmid= 11302733 |doi= 10.1006/bbrc.2001.4703
*cite journal | author=Kim JY, Kanai Y, Chairoungdua A, "et al." |title=Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells. |journal=Biochim. Biophys. Acta |volume=1512 |issue= 2 |pages= 335–44 |year= 2001 |pmid= 11406111 |doi=
*cite journal | author=Bassi MT, Gasol E, Manzoni M, "et al." |title=Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-. |journal=Pflugers Arch. |volume=442 |issue= 2 |pages= 286–96 |year= 2001 |pmid= 11417227 |doi=
*cite journal | author=Sasaki H, Sato H, Kuriyama-Matsumura K, "et al." |title=Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 44765–71 |year= 2003 |pmid= 12235164 |doi= 10.1074/jbc.M208704200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wang H, Tamba M, Kimata M, "et al." |title=Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 3 |pages= 611–8 |year= 2003 |pmid= 12763038 |doi=
*cite journal | author=Jiménez-Vidal M, Gasol E, Zorzano A, "et al." |title=Thiol modification of cysteine 327 in the eighth transmembrane domain of the light subunit xCT of the heteromeric cystine/glutamate antiporter suggests close proximity to the substrate binding site/permeation pathway. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11214–21 |year= 2004 |pmid= 14722095 |doi= 10.1074/jbc.M309866200
*cite journal | author=Gasol E, Jiménez-Vidal M, Chillarón J, "et al." |title=Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility. |journal=J. Biol. Chem. |volume=279 |issue= 30 |pages= 31228–36 |year= 2004 |pmid= 15151999 |doi= 10.1074/jbc.M402428200
*cite journal | author=Bridges CC, Hu H, Miyauchi S, "et al." |title=Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium. |journal=Invest. Ophthalmol. Vis. Sci. |volume=45 |issue= 9 |pages= 2906–14 |year= 2004 |pmid= 15326101 |doi= 10.1167/iovs.03-1355
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kaleeba JA, Berger EA |title=Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT. |journal=Science |volume=311 |issue= 5769 |pages= 1921–4 |year= 2006 |pmid= 16574866 |doi= 10.1126/science.1120878
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026PBB_Controls
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