ATP1A3

ATPase, Na+/K+ transporting, alpha 3 polypeptide, also known as ATP1A3, is a human gene.cite web | title = Entrez Gene: ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=478| accessdate = ]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lingrel JB, Orlowski J, Shull MM, Price EM |title=Molecular genetics of Na,K-ATPase. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=38 |issue= |pages= 37–89 |year= 1990 |pmid= 2158121 |doi=
*cite journal | author=Sverdlov ED, Monastyrskaia GS, Broude NE, "et al." |title= [The family of human Na+,K+-ATPase genes. Structure of the gene for isozyme alphaII] |journal=Dokl. Akad. Nauk SSSR |volume=297 |issue= 6 |pages= 1488–94 |year= 1988 |pmid= 2834163 |doi=
*cite journal | author=Ovchinnikov YuA , Monastyrskaya GS, Broude NE, "et al." |title=Family of human Na+, K+-ATPase genes. Structure of the gene for the catalytic subunit (alpha III-form) and its relationship with structural features of the protein. |journal=FEBS Lett. |volume=233 |issue= 1 |pages= 87–94 |year= 1988 |pmid= 2838329 |doi=
*cite journal | author=Yang-Feng TL, Schneider JW, Lindgren V, "et al." |title=Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. |journal=Genomics |volume=2 |issue= 2 |pages= 128–38 |year= 1988 |pmid= 2842249 |doi=
*cite journal | author=Sverdlov ED, Broude NE, Sverdlov VE, "et al." |title=Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism. |journal=FEBS Lett. |volume=221 |issue= 1 |pages= 129–33 |year= 1987 |pmid= 2887455 |doi=
*cite journal | author=Harley HG, Brook JD, Jackson CL, "et al." |title=Localization of a human Na+,K+-ATPase alpha subunit gene to chromosome 19q12----q13.2 and linkage to the myotonic dystrophy locus. |journal=Genomics |volume=3 |issue= 4 |pages= 380–4 |year= 1989 |pmid= 2907504 |doi=
*cite journal | author=Ovchinnikov YuA , Monastyrskaya GS, Broude NE, "et al." |title=The family of human Na+,K+-ATPase genes. A partial nucleotide sequence related to the alpha-subunit. |journal=FEBS Lett. |volume=213 |issue= 1 |pages= 73–80 |year= 1987 |pmid= 3030810 |doi=
*cite journal | author=Shull MM, Lingrel JB |title=Multiple genes encode the human Na+,K+-ATPase catalytic subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 12 |pages= 4039–43 |year= 1987 |pmid= 3035563 |doi=
*cite journal | author=Sverdlov ED, Monastyrskaya GS, Broude NE, "et al." |title=The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. |journal=FEBS Lett. |volume=217 |issue= 2 |pages= 275–8 |year= 1987 |pmid= 3036582 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Kramer PL, Mineta M, Klein C, "et al." |title=Rapid-onset dystonia-parkinsonism: linkage to chromosome 19q13. |journal=Ann. Neurol. |volume=46 |issue= 2 |pages= 176–82 |year= 1999 |pmid= 10443882 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Esplin MS, Fausett MB, Faux DS, Graves SW |title=Changes in the isoforms of the sodium pump in the placenta and myometrium of women in labor. |journal=Am. J. Obstet. Gynecol. |volume=188 |issue= 3 |pages= 759–64 |year= 2003 |pmid= 12634653 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=de Carvalho Aguiar P, Sweadner KJ, Penniston JT, "et al." |title=Mutations in the Na+/K+ -ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism. |journal=Neuron |volume=43 |issue= 2 |pages= 169–75 |year= 2004 |pmid= 15260953 |doi= 10.1016/j.neuron.2004.06.028
*cite journal | author=Benfante R, Antonini RA, Vaccari M, "et al." |title=The expression of the human neuronal alpha3 Na+,K+-ATPase subunit gene is regulated by the activity of the Sp1 and NF-Y transcription factors. |journal=Biochem. J. |volume=386 |issue= Pt 1 |pages= 63–72 |year= 2005 |pmid= 15462673 |doi= 10.1042/BJ20041294
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032

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