SLC4A4

Solute carrier family 4, sodium bicarbonate cotransporter, member 4, also known as SLC4A4, is a human gene.cite web | title = Entrez Gene: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8671| accessdate = ]

PBB_Summary
section_title =
summary_text = Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states. [supplied by OMIM] cite web | title = Entrez Gene: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8671| accessdate = ]

ee also

* Solute carrier family

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Romero MF, Boron WF |title=Electrogenic Na+/HCO3- cotransporters: cloning and physiology. |journal=Annu. Rev. Physiol. |volume=61 |issue= |pages= 699–723 |year= 1999 |pmid= 10099707 |doi= 10.1146/annurev.physiol.61.1.699
*cite journal | author=Soleimani M, Burnham CE |title=Physiologic and molecular aspects of the Na+:HCO3- cotransporter in health and disease processes. |journal=Kidney Int. |volume=57 |issue= 2 |pages= 371–84 |year= 2000 |pmid= 10652014 |doi= 10.1046/j.1523-1755.2000.00857.x
*cite journal | author=Burnham CE, Amlal H, Wang Z, "et al." |title=Cloning and functional expression of a human kidney Na+:HCO3- cotransporter. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19111–4 |year= 1997 |pmid= 9235899 |doi=
*cite journal | author=Abuladze N, Lee I, Newman D, "et al." |title=Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17689–95 |year= 1998 |pmid= 9651366 |doi=
*cite journal | author=Choi I, Romero MF, Khandoudi N, "et al." |title=Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC). |journal=Am. J. Physiol. |volume=276 |issue= 3 Pt 1 |pages= C576–84 |year= 1999 |pmid= 10069984 |doi=
*cite journal | author=Igarashi T, Inatomi J, Sekine T, "et al." |title=Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. |journal=Nat. Genet. |volume=23 |issue= 3 |pages= 264–6 |year= 1999 |pmid= 10545938 |doi= 10.1038/15440
*cite journal | author=Pushkin A, Yip KP, Clark I, "et al." |title=NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase. |journal=Am. J. Physiol. |volume=277 |issue= 6 Pt 2 |pages= F974–81 |year= 2000 |pmid= 10600945 |doi=
*cite journal | author=Park K, Hurley PT, Roussa E, "et al." |title=Expression of a sodium bicarbonate cotransporter in human parotid salivary glands. |journal=Arch. Oral Biol. |volume=47 |issue= 1 |pages= 1–9 |year= 2002 |pmid= 11743927 |doi=
*cite journal | author=Gross E, Hawkins K, Pushkin A, "et al." |title=Phosphorylation of Ser(982) in the sodium bicarbonate cotransporter kNBC1 shifts the HCO(3)(-) : Na(+) stoichiometry from 3 : 1 to 2 : 1 in murine proximal tubule cells. |journal=J. Physiol. (Lond.) |volume=537 |issue= Pt 3 |pages= 659–65 |year= 2002 |pmid= 11744745 |doi=
*cite journal | author=Gross E, Pushkin A, Abuladze N, "et al." |title=Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp(986), Asp(988) and kNBC1-carbonic anhydrase II binding. |journal=J. Physiol. (Lond.) |volume=544 |issue= Pt 3 |pages= 679–85 |year= 2003 |pmid= 12411514 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tatishchev S, Abuladze N, Pushkin A, "et al." |title=Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation. |journal=Biochemistry |volume=42 |issue= 3 |pages= 755–65 |year= 2003 |pmid= 12534288 |doi= 10.1021/bi026826q
*cite journal | author=Gross E, Fedotoff O, Pushkin A, "et al." |title=Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini. |journal=J. Physiol. (Lond.) |volume=549 |issue= Pt 3 |pages= 673–82 |year= 2004 |pmid= 12730338 |doi= 10.1113/jphysiol.2003.042226
*cite journal | author=Sun XC, Bonanno JA |title=Identification and cloning of the Na/HCO(3-) cotransporter (NBC) in human corneal endothelium. |journal=Exp. Eye Res. |volume=77 |issue= 3 |pages= 287–95 |year= 2003 |pmid= 12907161 |doi=
*cite journal | author=Yamada H, Yamazaki S, Moriyama N, "et al." |title=Localization of NBC-1 variants in human kidney and renal cell carcinoma. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 4 |pages= 1213–8 |year= 2003 |pmid= 14559244 |doi=
*cite journal | author=Alvarez BV, Loiselle FB, Supuran CT, "et al." |title=Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter. |journal=Biochemistry |volume=42 |issue= 42 |pages= 12321–9 |year= 2003 |pmid= 14567693 |doi= 10.1021/bi0353124
*cite journal | author=Becker HM, Deitmer JW |title=Voltage dependence of H+ buffering mediated by sodium bicarbonate cotransport expressed in Xenopus oocytes. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28057–62 |year= 2004 |pmid= 15123668 |doi= 10.1074/jbc.M402401200
*cite journal | author=Pushkin A, Abuladze N, Gross E, "et al." |title=Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells. |journal=J. Physiol. (Lond.) |volume=559 |issue= Pt 1 |pages= 55–65 |year= 2005 |pmid= 15218065 |doi= 10.1113/jphysiol.2004.065110

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