ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H, also known as ATP6V1H, is a human gene.cite web | title = Entrez Gene: ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51606| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the regulatory H subunit of the V1 domain which is required for catalysis of ATP but not the assembly of V-ATPase. Three alternatively spliced transcript variants encode two isoforms of the H subunit.cite web | title = Entrez Gene: ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51606| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Stevens TH, Forgac M |title=Structure, function and regulation of the vacuolar (H+)-ATPase. |journal=Annu. Rev. Cell Dev. Biol. |volume=13 |issue= |pages= 779–808 |year= 1998 |pmid= 9442887 |doi= 10.1146/annurev.cellbio.13.1.779
*cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580–5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141
*cite journal | author=Nishi T, Forgac M |title=The vacuolar (H+)-ATPases--nature's most versatile proton pumps. |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 2 |pages= 94–103 |year= 2002 |pmid= 11836511 |doi= 10.1038/nrm729
*cite journal | author=Pedersen PL |title=Transport ATPases in biological systems and relationship to human disease: a brief overview. |journal=J. Bioenerg. Biomembr. |volume=34 |issue= 5 |pages= 327–32 |year= 2003 |pmid= 12539959 |doi=
*cite journal | author=Kawasaki-Nishi S, Nishi T, Forgac M |title=Proton translocation driven by ATP hydrolysis in V-ATPases. |journal=FEBS Lett. |volume=545 |issue= 1 |pages= 76–85 |year= 2003 |pmid= 12788495 |doi=
*cite journal | author=Morel N |title=Neurotransmitter release: the dark side of the vacuolar-H+ATPase. |journal=Biol. Cell |volume=95 |issue= 7 |pages= 453–7 |year= 2004 |pmid= 14597263 |doi=
*cite journal | author=Lu X, Yu H, Liu SH, "et al." |title=Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. |journal=Immunity |volume=8 |issue= 5 |pages= 647–56 |year= 1998 |pmid= 9620685 |doi=
*cite journal | author=Lai CH, Chou CY, Ch'ang LY, "et al." |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=
*cite journal | author=Hu RM, Han ZG, Song HD, "et al." |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997
*cite journal | author=Mandic R, Fackler OT, Geyer M, "et al." |title=Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity. |journal=Mol. Biol. Cell |volume=12 |issue= 2 |pages= 463–73 |year= 2001 |pmid= 11179428 |doi=
*cite journal | author=Geyer M, Yu H, Mandic R, "et al." |title=Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28521–9 |year= 2002 |pmid= 12032142 |doi= 10.1074/jbc.M200522200
*cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins. |journal=Mol. Biol. Cell |volume=13 |issue= 6 |pages= 2045–56 |year= 2002 |pmid= 12058068 |doi= 02-02-0026
*cite journal | author=Lu M, Vergara S, Zhang L, "et al." |title=The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38409–15 |year= 2002 |pmid= 12163484 |doi= 10.1074/jbc.M203521200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Smith AN, Lovering RC, Futai M, "et al." |title=Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes. |journal=Mol. Cell |volume=12 |issue= 4 |pages= 801–3 |year= 2003 |pmid= 14580332 |doi=

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