GLUT2

protein
Name = solute carrier family 2 (facilitated glucose transporter), member 2
caption =


width =
HGNCid = 11006
Symbol = SLC2A2
AltSymbols = GLUT2
EntrezGene = 6514
OMIM = 138160
RefSeq = NM_000340
UniProt = P11168
PDB =
ECnumber =
Chromosome = 3
Arm = q
Band = 26
LocusSupplementaryData = .2-q27

GLUT 2 is a transmembrane carrier protein and gene which is involved in passive glucose transport, especially the renal glucose reabsorption.

Locations

It is found in cellular membranes of:
* liver
* pancreatic beta cells
* hypothalamus
* basolateral membrane of small intestine
* basolateral membrane of renal tubular cells

Function

It has high capacity but low affinity (high Km, ca. 5 mM) part of "the glucose sensor" in pancreatic β-cells. It is a very efficient carrier for glucose.

It may also carry glucosamine, suspected because mouse embryos lacking this glucose carrier protein/gene- and its suspected capacity to transport glucosamine- soon die. According to genetics researchers in neonatal and maternal-fetal medicine at Harvard University Medical School and Beth-Israel Deaconess Hospital Medical Center, this creates a problem for diabetic pregnancies in which glucose levels in the woman are uncontrolled, exposing her fetus to the possibility of neural tube and cardiac defects in the early-developing brain, spine, and heart.

ee also

* Glucose transporter

External links

* MeSH entry: [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=mesh&Cmd=ShowDetailView&TermToSearch=68051273&ordinalpos=1&itool=EntrezSystem2.PEntrez.Mesh.Mesh_ResultsPanel.Mesh_RVDocSum Glucose Transporter Type 2]