- ATP2B3
ATPase, Ca++ transporting, plasma membrane 3, also known as ATP2B3, is a human
gene .cite web | title = Entrez Gene: ATP2B3 ATPase, Ca++ transporting, plasma membrane 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=492| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: ATP2B3 ATPase, Ca++ transporting, plasma membrane 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=492| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Møller JV, Juul B, le Maire M |title=Structural organization, ion transport, and energy transduction of P-type ATPases. |journal=Biochim. Biophys. Acta |volume=1286 |issue= 1 |pages= 1–51 |year= 1996 |pmid= 8634322 |doi=
*cite journal | author=Strehler EE, Zacharias DA |title=Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. |journal=Physiol. Rev. |volume=81 |issue= 1 |pages= 21–50 |year= 2001 |pmid= 11152753 |doi=
*cite journal | author=Strehler EE, Treiman M |title=Calcium pumps of plasma membrane and cell interior. |journal=Curr. Mol. Med. |volume=4 |issue= 3 |pages= 323–35 |year= 2004 |pmid= 15101689 |doi=
*cite journal | author=Brandt P, Neve RL, Kammesheidt A, "et al." |title=Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels. |journal=J. Biol. Chem. |volume=267 |issue= 7 |pages= 4376–85 |year= 1992 |pmid= 1531651 |doi=
*cite journal | author=Stauffer TP, Hilfiker H, Carafoli E, Strehler EE |title=Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. |journal=J. Biol. Chem. |volume=269 |issue= 50 |pages= 32022 |year= 1995 |pmid= 7989379 |doi=
*cite journal | author=Wang MG, Yi H, Hilfiker H, "et al." |title=Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26-->p25 and Xq28, respectively. |journal=Cytogenet. Cell Genet. |volume=67 |issue= 1 |pages= 41–5 |year= 1994 |pmid= 8187550 |doi=
*cite journal | author=Stauffer TP, Hilfiker H, Carafoli E, Strehler EE |title=Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. |journal=J. Biol. Chem. |volume=268 |issue= 34 |pages= 25993–6003 |year= 1994 |pmid= 8245032 |doi=
*cite journal | author=Brown BJ, Hilfiker H, DeMarco SJ, "et al." |title=Primary structure of human plasma membrane Ca(2+)-ATPase isoform 3. |journal=Biochim. Biophys. Acta |volume=1283 |issue= 1 |pages= 10–3 |year= 1996 |pmid= 8765088 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Mallon AM, Platzer M, Bate R, "et al." |title=Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. |journal=Genome Res. |volume=10 |issue= 6 |pages= 758–75 |year= 2000 |pmid= 10854409 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Moreau R, Daoud G, Masse A, "et al." |title=Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta. |journal=Mol. Reprod. Dev. |volume=65 |issue= 3 |pages= 283–8 |year= 2004 |pmid= 12784250 |doi= 10.1002/mrd.10303
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Martin R, Harvey NC, Crozier SR, "et al." |title=Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual. |journal=Bone |volume=40 |issue= 5 |pages= 1203–8 |year= 2007 |pmid= 17336174 |doi= 10.1016/j.bone.2006.12.060PBB_Controls
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