- ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle, also known as ATP5A1, is a human
gene .cite web | title = Entrez Gene: ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=498| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the same protein have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16.cite web | title = Entrez Gene: ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=498| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=
*cite journal | author=Kataoka H, Biswas C |title=Nucleotide sequence of a cDNA for the alpha subunit of human mitochondrial ATP synthase. |journal=Biochim. Biophys. Acta |volume=1089 |issue= 3 |pages= 393–5 |year= 1991 |pmid= 1830491 |doi=
*cite journal | author=Kovalyov LI, Shishkin SS, Efimochkin AS, "et al." |title=The major protein expression profile and two-dimensional protein database of human heart. |journal=Electrophoresis |volume=16 |issue= 7 |pages= 1160–9 |year= 1996 |pmid= 7498159 |doi=
*cite journal | author=Abrahams JP, Leslie AG, Lutter R, Walker JE |title=Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria. |journal=Nature |volume=370 |issue= 6491 |pages= 621–8 |year= 1994 |pmid= 8065448 |doi= 10.1038/370621a0
*cite journal | author=Akiyama S, Endo H, Inohara N, "et al." |title=Gene structure and cell type-specific expression of the human ATP synthase alpha subunit. |journal=Biochim. Biophys. Acta |volume=1219 |issue= 1 |pages= 129–40 |year= 1994 |pmid= 8086450 |doi=
*cite journal | author=Jabs EW, Thomas PJ, Bernstein M, "et al." |title=Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier. |journal=Hum. Genet. |volume=93 |issue= 5 |pages= 600–2 |year= 1994 |pmid= 8168843 |doi=
*cite journal | author=Godbout R, Bisgrove DA, Honoré LH, Day RS |title=Amplification of the gene encoding the alpha-subunit of the mitochondrial ATP synthase complex in a human retinoblastoma cell line. |journal=Gene |volume=123 |issue= 2 |pages= 195–201 |year= 1993 |pmid= 8428659 |doi=
*cite journal | author=Godbout R, Pandita A, Beatty B, "et al." |title=Comparative genomic hybridization analysis of Y79 and FISH mapping indicate the amplified human mitochondrial ATP synthase alpha-subunit gene (ATP5A) maps to chromosome 18q12-->q21. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 253–6 |year= 1997 |pmid= 9284928 |doi=
*cite journal | author=Elston T, Wang H, Oster G |title=Energy transduction in ATP synthase. |journal=Nature |volume=391 |issue= 6666 |pages= 510–3 |year= 1998 |pmid= 9461222 |doi= 10.1038/35185
*cite journal | author=Wang H, Oster G |title=Energy transduction in the F1 motor of ATP synthase. |journal=Nature |volume=396 |issue= 6708 |pages= 279–82 |year= 1998 |pmid= 9834036 |doi= 10.1038/24409
*cite journal | author=Moser TL, Stack MS, Asplin I, "et al." |title=Angiostatin binds ATP synthase on the surface of human endothelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 6 |pages= 2811–6 |year= 1999 |pmid= 10077593 |doi=
*cite journal | author=Moser TL, Kenan DJ, Ashley TA, "et al." |title=Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 12 |pages= 6656–61 |year= 2001 |pmid= 11381144 |doi= 10.1073/pnas.131067798
*cite journal | author=Wang ZG, White PS, Ackerman SH |title=Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 30773–8 |year= 2001 |pmid= 11410595 |doi= 10.1074/jbc.M104133200
*cite journal | author=Chang SY, Park SG, Kim S, Kang CY |title=Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8388–94 |year= 2002 |pmid= 11741979 |doi= 10.1074/jbc.M108792200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sergeant N, Wattez A, Galván-valencia M, "et al." |title=Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease. |journal=Neuroscience |volume=117 |issue= 2 |pages= 293–303 |year= 2003 |pmid= 12614671 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Cross RL |title=Molecular motors: turning the ATP motor. |journal=Nature |volume=427 |issue= 6973 |pages= 407–8 |year= 2004 |pmid= 14749816 |doi= 10.1038/427407b
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051PBB_Controls
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