TCIRG1

TCIRG1

T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3, also known as TCIRG1, is a human gene.cite web | title = Entrez Gene: TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10312| accessdate = ]

PBB_Summary
section_title =
summary_text = Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis.cite web | title = Entrez Gene: TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10312| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Finbow ME, Harrison MA |title=The vacuolar H+-ATPase: a universal proton pump of eukaryotes. |journal=Biochem. J. |volume=324 ( Pt 3) |issue= |pages= 697–712 |year= 1997 |pmid= 9210392 |doi=
*cite journal | author=Stevens TH, Forgac M |title=Structure, function and regulation of the vacuolar (H+)-ATPase. |journal=Annu. Rev. Cell Dev. Biol. |volume=13 |issue= |pages= 779–808 |year= 1998 |pmid= 9442887 |doi= 10.1146/annurev.cellbio.13.1.779
*cite journal | author=Nelson N, Harvey WR |title=Vacuolar and plasma membrane proton-adenosinetriphosphatases. |journal=Physiol. Rev. |volume=79 |issue= 2 |pages= 361–85 |year= 1999 |pmid= 10221984 |doi=
*cite journal | author=Forgac M |title=Structure and properties of the vacuolar (H+)-ATPases. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12951–4 |year= 1999 |pmid= 10224039 |doi=
*cite journal | author=Kane PM |title=Introduction: V-ATPases 1992-1998. |journal=J. Bioenerg. Biomembr. |volume=31 |issue= 1 |pages= 3–5 |year= 1999 |pmid= 10340843 |doi=
*cite journal | author=Wieczorek H, Brown D, Grinstein S, "et al." |title=Animal plasma membrane energization by proton-motive V-ATPases. |journal=Bioessays |volume=21 |issue= 8 |pages= 637–48 |year= 1999 |pmid= 10440860 |doi= 10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W |doilabel=10.1002/(SICI)1521-1878(199908)21:8637::AID-BIES33.0.CO;2-W
*cite journal | author=Nishi T, Forgac M |title=The vacuolar (H+)-ATPases--nature's most versatile proton pumps. |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 2 |pages= 94–103 |year= 2002 |pmid= 11836511 |doi= 10.1038/nrm729
*cite journal | author=Kawasaki-Nishi S, Nishi T, Forgac M |title=Proton translocation driven by ATP hydrolysis in V-ATPases. |journal=FEBS Lett. |volume=545 |issue= 1 |pages= 76–85 |year= 2003 |pmid= 12788495 |doi=
*cite journal | author=Morel N |title=Neurotransmitter release: the dark side of the vacuolar-H+ATPase. |journal=Biol. Cell |volume=95 |issue= 7 |pages= 453–7 |year= 2004 |pmid= 14597263 |doi=
*cite journal | author=Li YP, Chen W, Stashenko P |title=Molecular cloning and characterization of a putative novel human osteoclast-specific 116-kDa vacuolar proton pump subunit. |journal=Biochem. Biophys. Res. Commun. |volume=218 |issue= 3 |pages= 813–21 |year= 1996 |pmid= 8579597 |doi= 10.1006/bbrc.1996.0145
*cite journal | author=Utku N, Heinemann T, Tullius SG, "et al." |title=Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein. |journal=Immunity |volume=9 |issue= 4 |pages= 509–18 |year= 1998 |pmid= 9806637 |doi=
*cite journal | author=Heinemann T, Bulwin GC, Randall J, "et al." |title=Genomic organization of the gene coding for TIRC7, a novel membrane protein essential for T cell activation. |journal=Genomics |volume=57 |issue= 3 |pages= 398–406 |year= 1999 |pmid= 10329006 |doi= 10.1006/geno.1999.5751
*cite journal | author=Frattini A, Orchard PJ, Sobacchi C, "et al." |title=Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis. |journal=Nat. Genet. |volume=25 |issue= 3 |pages= 343–6 |year= 2000 |pmid= 10888887 |doi= 10.1038/77131
*cite journal | author=Kornak U, Schulz A, Friedrich W, "et al." |title=Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis. |journal=Hum. Mol. Genet. |volume=9 |issue= 13 |pages= 2059–63 |year= 2000 |pmid= 10942435 |doi=

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