ATP1A2

ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide, also known as ATP1A2, is a human gene.cite web | title = Entrez Gene: ATP1A2 ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=477| accessdate = ]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lingrel JB, Orlowski J, Shull MM, Price EM |title=Molecular genetics of Na,K-ATPase. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=38 |issue= |pages= 37–89 |year= 1990 |pmid= 2158121 |doi=
*cite journal | author=Dunbar LA, Caplan MJ |title=Ion pumps in polarized cells: sorting and regulation of the Na+, K+- and H+, K+-ATPases. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29617–20 |year= 2001 |pmid= 11404365 |doi= 10.1074/jbc.R100023200
*cite journal | author=Shull MM, Pugh DG, Lingrel JB |title=Characterization of the human Na,K-ATPase alpha 2 gene and identification of intragenic restriction fragment length polymorphisms. |journal=J. Biol. Chem. |volume=264 |issue= 29 |pages= 17532–43 |year= 1989 |pmid= 2477373 |doi=
*cite journal | author=Sverdlov ED, Bessarab DA, Malyshev IV, "et al." |title=Family of human Na+,K+-ATPase genes. Structure of the putative regulatory region of the alpha+-gene. |journal=FEBS Lett. |volume=244 |issue= 2 |pages= 481–3 |year= 1989 |pmid= 2537767 |doi=
*cite journal | author=Yang-Feng TL, Schneider JW, Lindgren V, "et al." |title=Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. |journal=Genomics |volume=2 |issue= 2 |pages= 128–38 |year= 1988 |pmid= 2842249 |doi=
*cite journal | author=Shull MM, Lingrel JB |title=Multiple genes encode the human Na+,K+-ATPase catalytic subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 12 |pages= 4039–43 |year= 1987 |pmid= 3035563 |doi=
*cite journal | author=Sverdlov ED, Monastyrskaya GS, Broude NE, "et al." |title=The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. |journal=FEBS Lett. |volume=217 |issue= 2 |pages= 275–8 |year= 1987 |pmid= 3036582 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Zahler R, Gilmore-Hebert M, Baldwin JC, "et al." |title=Expression of alpha isoforms of the Na,K-ATPase in human heart. |journal=Biochim. Biophys. Acta |volume=1149 |issue= 2 |pages= 189–94 |year= 1993 |pmid= 8391840 |doi=
*cite journal | author=Stengelin MK, Hoffman JF |title=Na,K-ATPase subunit isoforms in human reticulocytes: evidence from reverse transcription-PCR for the presence of alpha1, alpha3, beta2, beta3, and gamma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 11 |pages= 5943–8 |year= 1997 |pmid= 9159180 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Ducros A, Joutel A, Vahedi K, "et al." |title=Mapping of a second locus for familial hemiplegic migraine to 1q21-q23 and evidence of further heterogeneity. |journal=Ann. Neurol. |volume=42 |issue= 6 |pages= 885–90 |year= 1998 |pmid= 9403481 |doi= 10.1002/ana.410420610
*cite journal | author=Terwindt GM, Ophoff RA, Lindhout D, "et al." |title=Partial cosegregation of familial hemiplegic migraine and a benign familial infantile epileptic syndrome. |journal=Epilepsia |volume=38 |issue= 8 |pages= 915–21 |year= 1998 |pmid= 9579893 |doi=
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=
*cite journal | author=Katzmarzyk PT, Rankinen T, Pérusse L, "et al." |title=Linkage and association of the sodium potassium-adenosine triphosphatase alpha2 and beta1 genes with respiratory quotient and resting metabolic rate in the Québec Family Study. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 6 |pages= 2093–7 |year= 1999 |pmid= 10372716 |doi=
*cite journal | author=Rankinen T, Pérusse L, Borecki I, "et al." |title=The Na(+)-K(+)-ATPase alpha2 gene and trainability of cardiorespiratory endurance: the HERITAGE family study. |journal=J. Appl. Physiol. |volume=88 |issue= 1 |pages= 346–51 |year= 2000 |pmid= 10642400 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ukkola O, Joanisse DR, Tremblay A, Bouchard C |title=Na+-K+-ATPase alpha 2-gene and skeletal muscle characteristics in response to long-term overfeeding. |journal=J. Appl. Physiol. |volume=94 |issue= 5 |pages= 1870–4 |year= 2003 |pmid= 12496141 |doi= 10.1152/japplphysiol.00942.2002

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