Mecloqualone

Mecloqualone
Mecloqualone
Systematic (IUPAC) name
3-(2-chlorophenyl)-2-methylquinazolin-4(3H)-one
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 340-57-8 YesY
ATC code None
PubChem CID 9567
ChemSpider 9192 YesY
UNII 09XU4VDV7E N
KEGG D04877 YesY
ChEMBL CHEMBL279960 YesY
Chemical data
Formula C15H11ClN2O 
Mol. mass 270.714
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Mecloqualone (Nubarene, Casfen) is an analogue of methaqualone which was first made in 1960[1] and marketed mainly in France and some other European countries. It has sedative, hypnotic and anxiolytic properties, and was used for the treatment of insomnia.[2] Mecloqualone is faster acting but shorter lasting than methaqualone and so was used only as a sleeping pill[3], in contrast to methaqualone which was used as a general purpose anxiolytic as well. Mecloqualone was never as widely used as methaqualone and is no longer prescribed because of concerns about its potential for abuse and overdose.

See also

References

  1. ^ Jackman, G. B.; Petrow, V.; Stephenson, O. (1960). "Some 2, 3-disubstituted 3H-4-quinazolones and 3H-4-thioquinazolones". The Journal of pharmacy and pharmacology 12: 529–538. PMID 14406263.  edit
  2. ^ Mouren, P.; Giraud, F.; Pinsard, N. (1963). "Clinical use of a new psycholeptic: Mecloqualone". Marseille medical 100: 599–602. PMID 13936358.  edit
  3. ^ Dubnk, B.; Towne, C. A.; Bush, M. T. (1969). "Detection, assay and rate of excretion of mecloqualone in animals and man". Toxicology and applied pharmacology 15 (3): 632–641. PMID 5353825.  edit
v · d · eHypnotics/Sedatives (N05C)
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