Diproqualone

Diproqualone
Diproqualone
Systematic (IUPAC) name
3-(2,3-dihydroxypropyl)-2-methyl-quinazolin-4-one
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 36518-02-2
ATC code None
PubChem CID 64112
ChemSpider 57691 YesY
UNII QY7HLH8V4L YesY
Chemical data
Formula C12H14N2O3 
Mol. mass 234.251
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Diproqualone is an analogue of methaqualone developed in the 1980s and marketed mainly in France and some other European countries. It has sedative, anxiolytic, antihistamine and analgesic properties, and is used primarily for the treatment of inflammatory pain associated with osteoarthritis and rheumatoid arthritis[1], and more rarely for treating insomnia, anxiety and neuralgia. [2]

Diproqualone is the only analogue of methaqualone that is still in widespread clinical use, due to its useful anti-inflammatory and analgesic effects in addition to the sedative and anxiolytic actions common to other drugs of this class. There are still some concerns about the potential of diproqualone for abuse and overdose, and so it is not sold as a pure drug but only as the camphosulfonate salt in combination mixtures with other medicines such as Ethenzamide.

See also

References

  1. ^ Audeval B, Bouchacourt P, Rondier J. Comparative study of diproqualone-ethenzamide versus glafenine for the treatment of rheumatic pain of gonarthrosis and coxarthrosis. (French) Gazette médicale de France 1988; 95(25):70-72
  2. ^ Substances Actives : CAMSILATE DE DIPROQUALONE
v · d · eHypnotics/Sedatives (N05C)
GABAA Agonists/PAMs
Barbiturates: Allobarbital • Amobarbital • Aprobarbital • Barbital • Butabarbital • Butobarbital • Cyclobarbital • Ethallobarbital • Heptabarbital • Hexobarbital • Mephobarbital • Methohexital • Pentobarbital • Phenobarbital • Proxibarbal • Reposal • Secobarbital • Talbutal • Thiamylal • Thiopental • Vinbarbital • Vinylbital; Benzodiazepines: Brotizolam • Cinolazepam • Climazolam • Doxefazepam • Estazolam • Flunitrazepam • Flurazepam • Flutoprazepam • Haloxazolam • Loprazolam • Lormetazepam • Midazolam • Nimetazepam • Nitrazepam • Quazepam • Temazepam • Triazolam; Carbamates: Carisoprodol • Ethinamate • Hexapropymate • Meprobamate • Methocarbamol • Procymate • Tybamate; Neuroactive Steroids: Acebrochol • Allopregnanolone • Alphadolone • Alphaxolone • Eltanolone • Ganaxolone • Hydroxydione • Minaxolone • Org 20599 • Org 21465 • Tetrahydrodeoxycorticosterone; Nonbenzodiazepines: CL-218,872 • Eszopiclone • Indiplon • JM-1232 • Lirequinil • Necopidem • Pazinaclone • ROD-188 • Saripidem • Suproclone • Suriclone • SX-3228 • U-89843A • U-90042 • Zaleplon • Zolpidem • Zopiclone; Phenols: Fospropofol • Propofol; Piperidinediones: Glutethimide • Methyprylon • Pyrithyldione • Piperidione; Quinazolinones: Afloqualone • Cloroqualone • Diproqualone • Etaqualone • Mebroqualone • Mecloqualone • Methaqualone • Methylmethaqualone • Nitromethaqualone; Others: 2-Methyl-2-butanol • Acetophenone • Acetylglycinamide chloral hydrate • Bromide (Lithium bromide, Potassium bromide, Sodium bromide) • Centalun • Chloral hydrate • Chloralose • Chloralodol • Clomethiazole • Dichloralphenazone • Ethanol (Alcohol) • Ethchlorvynol • Etomidate • Gaboxadol • Loreclezole • Methylpentynol • Metomidate • Paraldehyde • Petrichloral • Sulfonmethane • Trichloroethanol • Triclofos • Valerenic acid (Valerian)
GABAB Agonists
1,4-Butanediol • Aceburic acid • GABOB • GHB • GBL • GVL
H1 Inverse agonists
α1-Adrenergic Antagonists
α2-Adrenergic Agonists
5-HT2A Antagonists
Melatonin Agonists
Agomelatine • LY-156,735 • Melatonin • Ramelteon • Tasimelteon
Orexin Antagonists
Almorexant • SB-334,867 • SB-408,124 • SB-649,868 • Suvorexant • TCS-OX2-29
Others


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