Pazinaclone

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IUPAC_name = 2-(7-chloro-1,8-naphthyridin-2-yl)-3- [2-(1,4-dioxa-8- azaspiro [4.5] decan-8-yl)-2-oxoethyl] -3H-isoindol-1-one

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CAS_number = 103255-66-9
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PubChem = 59743
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C = 25 | H = 23 | Cl = 1 | N = 4 | O = 4
molecular_weight = 478.928 g/mol
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Pazinaclone (DN-2327) is a sedative and anxiolytic drug in the cyclopyrrolone family of drugs. Other cyclopyrrolone drugs include zopiclone and eszopiclone.

Pazinaclone has a very similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties, but with less amnestic effects, [Wada T, Fukuda N. Effect of a new anxiolytic, DN-2327, on learning and memory in rats. Pharmacology, Biochemistry and Behavior. 1992 Mar;41(3):573-9.] and at low doses it is a relatively selective anxiolytic, with sedative effects only appearing at higher doses. [Suzuki M, Uchiumi M, Murasaki M. A comparative study of the psychological effects of DN-2327, a partial benzodiazepine agonist, and alprazolam. Psychopharmacology (Berlin). 1995 Oct;121(4):442-50.]

Pazinaclone produces its sedative and anxiolytic effects by acting as a partial agonist at GABA_A benzodiazepine receptors, although pazinaclone is more subtype-selective than most benzodiazepines. [Atack JR. The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics. Expert Opinion on Investigational Drugs. 2005 May;14(5):601-18.]

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