SX-3228

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IUPAC_name = 5,6,7,8-Tetrahydro-3-(5-methoxy-1,3,4-oxadiazol-2-yl)- 6-(phenylmethyl)-1,6-naphthyridin-2(1H)-one

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CAS_number = 156364-04-4
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PubChem = 5487538
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C=18|H=18|N=4|O=3
molecular_weight = 338.361 g/mol
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SX-3228 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.

SX-3228 is a subtype-selective GABA_A agonist acting primarily at the α1 subtype. It thus has similar effects to other α1-selective drugs such as zolpidem and zaleplon in animal studies. [Sanger DJ. The effects of new hypnotic drugs in rats trained to discriminate ethanol. "Behavioural Pharmacology". 1997 Aug;8(4):287-92.] [Griebel G, Perrault G, Tan S, Schoemaker H, Sanger DJ. Comparison of the pharmacological properties of classical and novel BZ-omega receptor ligands. "Behavioural Pharmacology". 1999 Sep;10(5):483-95.] It only partly substitutes for ethanol, and is a strong sedative-hypnotic with only limited anxiolytic effects which appear only at doses that also produce significant sedation. [Griebel G, Perrault G, Sanger DJ. Limited anxiolytic-like effects of non-benzodiazepine hypnotics in rodents. "Journal of Psychopharmacology". 1998;12(4):356-65.] [Alvariño F, Monti JM, Jantos H, Monti D. Effect of SX-3228, a selective ligand for the BZ1 receptor, on sleep and waking during the light-dark cycle in the rat. "Brazilian Journal of Medical and Biological Research". 1999 Aug;32(8):1007-14.]

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