Goblet cell

Goblet cell
Goblet cell
Section of mucus membrane of human stomach, near the cardiac orifice. X 45.
c. Cardiac glands.
d. Their ducts.
cr. Gland similar to the intestinal glands, with goblet cells.
mm. Mucous membrane.
m. Muscularis mucosae.
m’. Muscular tissue within the mucous membrane.
Transverse section of a villus, from the human intestine. X 350.
a. Basement membrane, here somewhat shrunken away from the epithelium.
b. Lacteal.
c. Columnar epithelium.
d. Its striated border.
e. Goblet cells.
f. Leucocytes in epithelium.
f’. Leucocytes below epithelium.
g. Blood vessels.
h. Muscle cells cut across.
Latin exocrinocytus caliciformis
Code TH H3.;

Goblet cells are glandular simple columnar epithelial cells whose sole function is to secrete mucin, which dissolves in water to form mucus. They use both apocrine and merocrine methods for secretion.

The majority of the cell's cytoplasm is occupied by mucinogen granules, except at the bottom. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion. Recent study suggests that glycoprotein is located inside goblet cells. It is an organ-specific antigen in the gut.



They are found scattered among the epithelial lining of organs, such as the intestinal and respiratory tracts.[1] They are found inside the trachea, bronchus, and larger bronchioles in respiratory tract, small intestines, the colon, and conjunctiva in the upper eyelid.

They may be an indication of metaplasia, such as in Barrett's esophagus.


In mucicarmine stains, deep red mucin found within goblet cell bodies.

The nuclei of goblet cells tend to be displaced toward the basal end of the cell body, leading to intense basophilic staining.


The term goblet refers to these cells' goblet-like shape. The apical portion is shaped like a cup, as it is distended by abundant mucinogen granules; its basal portion is shaped like a stem, as it is narrow for lack of these granules.

There are other cells that secrete mucus (as in the foveolar cells of the stomach[2]), but they are not usually called "goblet cells" because they do not have this distinctive shape.

Basal secretion

This is the normal base level secretion of mucus, which is accomplished by cytoskeletal movement of secretory granules.

Stimulated secretion

Secretion may be stimulated by dust, smoke, etc.

Other stimuli include viruses, bacteria, etc.

See also

Additional images


  1. ^ "goblet cell" at Dorland's Medical Dictionary
  2. ^ Histology at BU 11303loa - Digestive System: Alimentary Canal: fundic stomach, gastric glands, lumen"

External links

Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • goblet cell — gob·let cell gäb lət n a mucus secreting epithelial cell (as of columnar epithelium) that is distended with secretion or its precursors at the free end * * * a column shaped secretory cell found in the epithelium of the respiratory and intestinal …   Medical dictionary

  • Goblet cell carcinoid — Classification and external resources Micrograph showing a goblet cell carcinoid. H E stain. The goblet cell carcinoid, abbreviated GCC and …   Wikipedia

  • goblet cell — Cell Biol. a type of epithelial cell that secretes mucin, so called after its shape. [1875 80] * * * …   Universalium

  • goblet cell — gob′let cell n. cbl a goblet shaped epithelial cell that secretes mucin …   From formal English to slang

  • goblet cell — a column shaped secretory cell found in the epithelium of the respiratory and intestinal tracts. Goblet cells secrete the principal constituents of mucus …   The new mediacal dictionary

  • goblet cell — (1) Cell of the epithelial lining of small intestine that secretes mucus and has a very well developed Golgi apparatus. (2) Cell type characteristic of larval lepidopteran midgut, containing a potent H+ ATPase, and thought to be involved in… …   Dictionary of molecular biology

  • goblet cell — noun an epithelial cell that secretes mucous • Hypernyms: ↑epithelial cell …   Useful english dictionary

  • goblet cell — noun Etymology: from its shape Date: 1878 a mucus secreting epithelial cell (as of intestinal columnar epithelium) that is distended at the free end …   New Collegiate Dictionary

  • goblet cell — see calyciform cell …   Dictionary of invertebrate zoology

  • goblet cell — noun Anatomy a column shaped cell found in the respiratory and intestinal tracts, which secretes the main component of mucus …   English new terms dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”