- Enterochromaffin cell
They produce and contain about 90% of the body's store of
In the gastrointestinal tract, 5-HT is important in response to chemical, mechanical or
pathologicalstimuli in the lumen. It activates both secretory and peristalticreflexes, and activates vagalafferents (via 5-HT3 receptors) that signal to the brain (important in the generation of nausea). Ondansetronis an antagonist of the 5-HT3 receptor and is an effective anti-emetic.
They are called "entero" [ [http://www.medterms.com/script/main/art.asp?articlekey=3258 Entero- definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms ] ] meaning related to the gut and "chromaffin" because of a
chromiumsalt reaction that they share with chromaffin cells of the adrenal medulla( adrenal glands). [GPnotebook|1516961798]
Another population of chromaffin cells is found only in the stomach wall, called
enterochromaffin-like cells (ECL). They look like EC cells but do not contain 5-HT.
ECL cells respond to
acetylcholinereleased by the vagus nerveand they in turn release histamine, which will stimulate the parietal cellsto produce gastric acid.
Kulchitsky cells, or neuroendocrine cells, have been implicated in the origin of
small cell lung cancer. [ [http://www.emedicine.com/radio/topic405.htm eMedicine - Lung Cancer, Small Cell : Article by Abid Irshad ] ]
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