Infobox Anatomy
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Caption = LAYERS:
longitudinal muscle
myenteric plexus
circular muscle
submucosal plexus

Caption2 = Endoscopy and radial endoscopic ultrasound images of submucosal tumour in mid-esophagus. The submucosa is seen as a dark ring on the ultrasound image.
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DorlandsPre = s_27
DorlandsSuf = 12765896

In the gastrointestinal tract, the submucosa is the layer of loose connective tissue that supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle (fibers running circularly within layer of longitudinal muscle).


Blood vessels, lymphatic vessels, and nerves (all supplying the mucosa) will run through here.

Tiny parasympathetic ganglia are scattered around forming the submucosal plexus (or "Meissner's plexus") where preganglionic parasympathetic neurons synapse with postganglionic nerve fibers that supply the muscularis mucosae.

The submucosa in endoscopy

Identification of the submucosa plays an important role in diagnostic and therapeutic endoscopy, where special fibre-optic cameras are used to perform procedures on the gastrointestinal tract. Abnormalities of the submucosa, such as gastrointestinal stromal tumors, usually show integrity of the mucosal surface.

The submucosa is also identified in endoscopic ultrasound to identify the depth of tumours and to identify other abnormalities. An injection of dye, saline, or epinephrine into the submucosa is imperative in the safe removal of certain polyps.

Endoscopic mucosal resection involves removal of the mucosal layer, and in order to be done safely, a submucosal injection of dye is performed to ensure integrity at the beginning of the procedure.

ee also

* Small intestinal submucosa


External links

* - "Mammal, whole system (LM, Low)"
* - "Tissues, Layers, and Organs: transverse section of rat gut"
* - "Duodenum and Jejunum"
* [ Histology at]

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Look at other dictionaries:

  • submucosa — f. histol. Tejido celular que se halla situado debajo de una mucosa. Medical Dictionary. 2011 …   Diccionario médico

  • Submucosa — Unter dem Begriff Tela submucosa versteht man in der Histologie die Gewebsschicht im Magen Darm Trakt zwischen der Schleimhaut (Tunica mucosa) und der Muskelschicht (Tunica muscularis). Die Tela submucosa besteht aus lockerem Bindegewebe, vielen… …   Deutsch Wikipedia

  • Submucosa — La submucosa es la capa de tejido que está situada debajo de la mucosa. En el tubo digestivo ocupa el espesor de la pared, entre la capa muscular de la mucosa y la capa muscular propia. La capa submucosa está formada por tejido conjuntivo denso… …   Wikipedia Español

  • submucosa — A layer of tissue beneath a mucous membrane; the layer of connective tissue beneath the tunica mucosa. SYN: tela s., tunica s.. * * * sub·mu·co·sa .səb myü kō sə n a supporting layer of loose connective tissue directly under a mucous membrane… …   Medical dictionary

  • submucosa — [ˌsʌbmju: kəʊsə] noun (plural submucosae si:) Physiology the layer of areolar connective tissue lying beneath a mucous membrane. Derivatives submucosal adjective Origin C19: from mod. L. submucosa (membrana), feminine of submucosus submucous …   English new terms dictionary

  • submucosa of bladder — tela submucosa vesicae urinariae …   Medical dictionary

  • submucosa of bronchus — tela submucosa bronchi …   Medical dictionary

  • submucosa of esophagus — tela submucosa oesophagi …   Medical dictionary

  • submucosa of large intestine — tela submucosa intestini crassi …   Medical dictionary

  • submucosa of pharynx — tela submucosa pharyngis …   Medical dictionary

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