Sucrose intolerance

Sucrose intolerance
Classification and external resources
Sucrose
ICD-10	E74.3
ICD-9	271.3
OMIM	222900
DiseasesDB	29844

Sucrose intolerance, also called congenital sucrase-isomaltase deficiency (CSID)^[1] or Sucrase-isomaltase deficiency,^[2] is the condition in which sucrase, an enzyme needed for proper metabolization of sucrose, is not produced in the small intestine.

It is more common among the Inupiat.^[3]

Overview

Sucrose (also known as saccharose) is a disaccharide (simple sugars) composed of glucose and fructose, which are bonded together. A more familiar name is table, beet, or cane sugar. In most cases, sucrose intolerance is an autosomal recessive genetic metabolic disease, which is a digestive deficiency of the enzyme sucrase. Foods containing single sugars, allows the body to absorb them directly into your blood. However, when you eat disaccharides you must digest them first. Intestinal cells contain enzymes that are responsible for splitting disaccharides into monosaccharides (single sugar unit) in order for them to enter the bloodstream. Products in which are digested are delivered from the blood to the liver. This allows enzymes to modify nutrients. Sucrose can sometimes be found in the stool as an indication of an inability to digest and absorb sucrose in the body.

A deficiency of sucrose may result in malabsorption of sugar, which can lead to more serious symptoms. It is important to discard as many sugar containing foods from the diet when sucrose intolerant. Foods such as fruit and starch can help heal the body and reduce some symptoms. Supplements can be taken as a substitution of the enzyme missing or to welcome healthy bacteria into the immune system.

Sucrose Intolerance (Congenital sucrase-isomaltase enzyme deficiency) can be caused by genetic mutations (the common ones being SI and SII), in which both parents must contain this gene in order for the child to carry the disease. Sucrose intolerance can also be caused by irritable bowel syndrome, aging, or small intestine disease. There are specific tests used to determine sucrose intolerance. The most common tests are the sucrose breath test, genetic analysis or enzyme activity determination, which takes place in the small intestine.

Symptoms of Sucrose Intolerance

• Abdominal cramps and bloating
• Diarrhea and constipation
• Vomiting
• Hypoglycemia and headaches
• Poor weight gain and growth
• Upper respiratory tract and viral infections
• Anxiety and heart palpitations
• Excess gas production

See also

• Fructose malabsorption
• Gastroenterology
• Lactose intolerance
• Sucrase-isomaltase

References

1. ^ Sander P, Alfalah M, Keiser M, et al. (January 2006). "Novel mutations in the human sucrase-isomaltase (SI) gene that cause congenital carbohydrate malabsorption". Hum. Mutat. 27 (1): 119. doi:10.1002/humu.9392. PMID 16329100. 
2. ^ Baudon JJ, Veinberg F, Thioulouse E, Morgant G, Aymard P, Charritat JL (April 1996). "Sucrase-isomaltase deficiency: changing pattern over two decades". J. Pediatr. Gastroenterol. Nutr. 22 (3): 284–8. doi:10.1097/00005176-199604000-00010. PMID 8708882. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0277-2116&volume=22&issue=3&spage=284. 
3. ^ Meier RJ, Draper H, Milan F (January 1991). "Pedigree analysis of sucrose intolerance among Native Alaskans". Arctic Med Res 50 (1): 8–12. PMID 2021397. 

External links

• http://www.csidinfo.com/
• http://www.orphan-europe.com/sucrase_mangel_gb.html
• http://www.sucraid.net/

This medical symptom article is a stub. You can help Wikipedia by expanding it.v · Categories: Inborn errors of carbohydrate metabolism Symptom stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Tim Buckley (coach) John Coalter Look at other dictionaries: Intolerance — is an antonym to tolerance . The term may refer to one of the following.;Medical/biological conditionsIn medical/biological context the term is commonly used synonymously with sensitivity , e.g., salycylate sensitivity , cold sensitivity ,… …   Wikipedia congenital sucrose intolerance — a disaccharide intolerance specific for sucrose, usually due to a congenital defect in the sucrase isomaltase enzyme complex; see sucrase isomaltase deficiency, under deficiency …   Medical dictionary Intolerance au saccharose — Déficience en sucrase isomaltase Déficience en sucrase isomaltase Autre nom {{{Autre nom}}} Référence MIM …   Wikipédia en Français Intolérance au saccharose — Déficience en sucrase isomaltase Déficience en sucrase isomaltase Autre nom {{{Autre nom}}} Référence MIM …   Wikipédia en Français Lactose intolerance — Classification and external resources Lactose (disaccharide of β D galactose β D glucose) is normally split by lactase. ICD 10 …   Wikipedia Food intolerance — or food sensitivity is a negative reaction to a food that may or may not be related to the immune system or to food poisoning. It can be caused by the absence of specific chemicals or enzymes needed to digest a food substance, or to the body s… …   Wikipedia Hereditary fructose intolerance — DiseaseDisorder infobox Name = Fructose intolerance ICD10 = ICD10|E|74|1|e|70 ICD9 = ICD9|271.2 ICDO = Caption = Fructose OMIM = 229600 MedlinePlus = 000359 eMedicineSubj = ped eMedicineTopic = 988 DiseasesDB = 5003 MeshID = D005633 Hereditary… …   Wikipedia Fructose malabsorption — Classification and external resources Fructose ICD 10 E …   Wikipedia Sucrase — is the name given to a number of enzymes that catalyze the hydrolysis of sucrose to fructose and glucose. The enzyme invertase, which occurs more commonly in plants, also hydrolyzes sucrose but by a different mechanism.[1] Contents 1 Types 2 …   Wikipedia Glucose-galactose malabsorption — Classification and external resources ICD 10 E74.3 ICD 9 271.3 …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”