Hexose

In organic chemistry, a hexose is a monosaccharide with six carbon atoms, having the chemical formula C₆H₁₂O₆. Hexoses are classified by functional group, with aldohexoses having an aldehyde at position 1, and ketohexoses having a ketone at position 2.

Aldohexoses

The aldohexoses have four chiral centres for a total of 16 possible aldohexose stereoisomers (2⁴). The D/L configuration is based on the orientation of the hydroxyl at position 5, and does not refer to the direction of optical activity.The eight D-aldohexoses are:

CH=O CH=O CH=O CH=O
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HC-OH HO-CH HC-OH HO-CH
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HC-OH HC-OH HO-CH HO-CH
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HC-OH HC-OH HC-OH HC-OH
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HC-OH HC-OH HC-OH HC-OH
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CH₂OH CH₂OH CH₂OH CH₂OH D-Allose D-Altrose D-Glucose D-Mannose

CH=O CH=O CH=O CH=O
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HC-OH HO-CH HC-OH HO-CH
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HC-OH HC-OH HO-CH HO-CH
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HO-CH HO-CH HO-CH HO-CH
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HC-OH HC-OH HC-OH HC-OH
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CH₂OH CH₂OH CH₂OH CH₂OH D-Gulose D-Idose D-Galactose D-Talose

Of these D isomers, all except altrose are naturally occurring. L-altrose has been isolated from strains of the bacterium Butyrivibrio fibrisolvens. [Ref patent
country=US |number=4966845 |title=Microbial production of L-altrose |invent1=Stack; Robert J. |status= patent |gdate=1990-10-30
assign1=Government of the United States of America, Secretary of Agriculture
class=]

A mnemonic (attributed to Louis Fieser) often employed to remember the eight aldohexoses is "all altruists gladly make gum in gallon tanks".

Cyclic Hemiacetals

It has been known since 1926 that 6-carbon aldose sugars form cyclic hemiacetals.cite book|author=Morrison, Robert Thornton and Boyd, Robert Neilson|title=Organic Chemistry|, 2nd ed.|publisher=Allyn and Bacon Library of Congress catalog 66-25695] The diagram below shows the hemiacetal forms for D-glucose and D-mannose.

:

The numbered carbons in the open-chain forms correspond to the same numbered carbons in the hemiacetal forms. The formation of the hemiacetal causes carbon number 1, which is symmetric in the open-chain form, to become asymmetric in the cyclic version. This means that both glucose and mannose (as well as all the other aldohexoses) each have two cyclic forms. In solution, both of these exist in equilibrium with the open-chain form. The open-chain form, however, does not crystallize. Hence the two cyclic forms become separable when they are crystallized. For example, D-glucose forms an alpha crystal that has specific rotation of +112° and melting point of 146 °C, as well as a beta crystal that has specific rotation of +19° and melting point of 150 °C.

Ketohexoses

The ketohexoses have 3 chiral centres and therefore eight possible stereoisomers (2³). Of these, only the four D-isomers are known to occur naturally: CH₂OH CH₂OH CH₂OH CH₂OH
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C=O C=O C=O C=O
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HC-OH HO-CH HC-OH HO-CH
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HC-OH HC-OH HO-CH HO-CH
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HC-OH HC-OH HC-OH HC-OH
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CH₂OH CH₂OH CH₂OH CH₂OH D-psicose D-fructose D-sorbose D-tagatose

Only the naturally occurring hexoses are capable of being fermented by yeasts.

Mutarotation

The aldehyde and ketone functional groups in these carbohydrates react with neighbouring hydroxyl functional groups to form intramolecular hemiacetals and hemiketals, respectively. The resulting ring structure is related to pyran, and is termed a pyranose. The ring spontaneously opens and closes, allowing rotation to occur about the bond between the carbonyl group and the neighbouring carbon atom, yielding two distinct configurations (α and β). This process is termed mutarotation. Hexose sugars can form dihexose sugars with a condensation reaction to form a 1,6-glycosidic bond.

References

ee also

* Triose
* Tetrose
* Pentose
* Heptose
* Glucose