Glucose-6-phosphate dehydrogenase deficiency

Glucose-6-phosphate dehydrogenase deficiency

] The discovery of G6PD deficiency relieved heavily upon the testing of prisoner volunteers at Illinois State Penitentiary, although today such studies cannot be performed. When some prisoners were given the drug primaquine, some developed hemolytic anemia but others did not. After studying the mechanism through Cr51 testing, it was conclusively shown that the hemolytic effect of primaquine was due to an internal defect of erythrocytes.cite journal |author=Beutler E |title=Glucose-6-phosphate dehydrogenase deficiency: a historical perspective |journal=Blood |volume=111 |issue=1 |pages=16–24 |year=2008 |month=January |pmid=18156501 |doi=10.1182/blood-2007-04-077412 |url=http://bloodjournal.hematologylibrary.org/cgi/content/full/111/1/16]

References

External links

* [http://www.rialto.com/g6pd/ The G6PD homepage]
* [http://www.bioinf.org.uk/g6pd/ The G6PDdb] - genetic and structural information database about glucose-6-phosphate dehydrogenase deficiency
* [http://www.g6pd.org/ G6PD Deficiency Association]
* [http://www.rddiagnostics.com/g6pd_faq.htm A FAQ page on G6PD Deficiency by R&D Diagnostics]
* [http://www.fpnotebook.com/Hemeonc/Hemolysis/G6pdDfcncy.htm Family Practice Notebook/G6PD Deficiency (Favism)]


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  • glucose-6-phosphate dehydrogenase deficiency — n a hereditary metabolic disorder affecting red blood cells that is controlled by a variable gene on the X chromosome, that is characterized by a deficiency of glucose 6 phosphate dehydrogenase conferring marked susceptibility to hemolytic anemia …   Medical dictionary

  • glucose-6-phosphate dehydrogenase deficiency — glucose 6 phosphate dehydrogenase deficiency. См. дефицит глюкозо 6 фосфатдегидрогеназы. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • glucose-6-phosphate dehydrogenase deficiency — a hereditary (X linked) condition in which the absence of the enzyme glucose 6 phosphate dehydrogenase (G6PD), which functions in carbohydrate metabolism, results in the breakdown of the red blood cells (haemolysis), usually after exposure to… …   Medical dictionary

  • glucose-6-phosphate dehydrogenase deficiency — a hereditary (X linked) condition in which the absence of the enzyme glucose 6 phosphate dehydrogenase (G6PD), which functions in carbohydrate metabolism, results in the breakdown of the red blood cells (haemolysis), usually after exposure to… …   The new mediacal dictionary

  • glucose-6-phosphate dehydrogenase deficiency — ▪ pathology       hereditary metabolic defect characterized by an increased tendency of the red blood cells to break and release their hemoglobin (hemolysis), especially after the intake of certain drugs. The condition is caused, as the name… …   Universalium

  • Glucose-6-phosphate dehydrogenase — NOTOC Glucose 6 phosphate dehydrogenase (G6PD) is a cytosolic enzyme in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the co enzyme… …   Wikipedia

  • glucose-6-phosphate dehydrogenase — An NADP+ enzyme catalyzing the dehydrogenation of d glucose 6 phosphate to 6 phospho d glucono δ lactone, this reaction initiating the pentose shunt. A deficiency of this enzyme can lead to severe hemolytic …   Medical dictionary

  • Deficiency, glucose-6-phosphate dehydrogenase (G6PD) — Deficiency of G6PD is the commonest disease causing enzyme defect in humans affecting an estimated 400 million people. The G6PD gene is on the X chromosome. Males with the enzyme deficiency develop anemia due to breakup of their red blood cells… …   Medical dictionary

  • Glucose-6-phosphate dehydrogenase (G6PD) — Deficiency of G6PD is the commonest disease causing enzyme defect in humans affecting an estimated 400 million people. The G6PD gene is on the X chromosome. Males with the enzyme deficiency develop anemia due to breakup of their red blood cells… …   Medical dictionary

  • Дефицит Глюкозо-6Фосфат-Дегидрогеназы (Glucose- 6-Phosphate Dehydrogenase Deficiency) — наследственное заболевание, при котором у человека отсутствует фермент глюкозо 6фосфат дегидрогеназа, участвующий в углеводном обмене. Проявляется оно в детстве, вызывая увеличение печени и снижение уровня сахара в крови. В процессе лечения… …   Медицинские термины

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