Sucrase

Sucrase is the name given to a number of enzymes that catalyze the hydrolysis of sucrose to fructose and glucose. The enzyme invertase, which occurs more commonly in plants, also hydrolyzes sucrose but by a different mechanism.^[1]

Types

• EC 3.2.1.10 is sucrase-isomaltase
• EC 3.2.1.26 is invertase
• EC 3.2.1.48

Physiology

Sucrose intolerance (also known as Congenital Sucrase-Isomaltase Deficiency (CSID) or Sucrase-isomaltase deficiency) occurs when sucrase is not secreted in the small intestine. With sucrose intolerance, the result of consuming sucrose is excess gas production and often diarrhea and malabsorption. Lactose intolerance is a related disorder that reflects an individual's inability to hydrolyze the disaccharide lactose.

Sucrase is secreted by the tips of the villi of the epithelium in the small intestine. Its levels are reduced in response to villi-blunting events such as celiac sprue and the inflammation associated with the disorder. The levels increase in Pregnancy/Lactation and Diabetes as the villi hypertrophy.

Use in chemical analysis

Sucrose itself is a non-reducing sugar and therefore will not test positive with Benedict's solution. In order to test for sucrose, the sample is treated with sucrase. The sucrose is hydrolysed into glucose and fructose, with glucose being a reducing sugar, which in turns tests positive with Benedict's solution^{[citation needed]}.

References

1. ^ Hubert Schiweck, Margaret Clarke, Günter Pollach "Sugar” in Ullmann’s Encyclopedia of Industrial Chemistry 2007, Wiley-VCH, Weinheim. doi:10.1002/14356007.a25_345.pub2

External links

• MeSH Sucrase

This hydrolase article is a stub. You can help Wikipedia by expanding it.v · Categories: EC 3.2.1 Hydrolase stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Red Jew Oscar K. Allen Look at other dictionaries: Sucrase — Isomaltase Größe 1826 Aminosäuren Struktur single pass Typ 2 Membranprotein Bezeichner …   Deutsch Wikipedia sucrase — [ sykraz ] n. f. • 1903; de sucre et ase ♦ Biochim. Saccharase. ● sucrase nom féminin Synonyme de invertase. ● sucrase (synonymes) nom féminin Synonymes : invertase …   Encyclopédie Universelle sucrase — [so͞o′krās΄] n. [< Fr sucre,SUGAR + ASE] an enzyme present in certain plant and animal tissues that catalyzes the hydrolysis of sucrose into glucose and fructose …   English World dictionary Sucrase — Saccharase La saccharase ou sucrase est une enzyme qui scinde le saccharose en une molécule de fructose et une de glucose. Cette enzyme, secrétée par les cryptes de Lieberkühn, est présente dans la muqueuse intestinale. Si la saccharase n est pas …   Wikipédia en Français sucrase — /sooh krays, krayz/, n. Biochem. invertase. [1895 1900; < F sucre SUGAR + ASE] * * * ▪ enzyme also called  Invertase,         any member of a group of enzymes present in yeast and in the intestinal mucosa of animals that catalyze the hydrolysis… …   Universalium sucrase — SYN: sucrose α d glucohydrolase. * * * su·crase sü .krās, .krāz n INVERTASE * * * n. an enzyme, secreted by glands in the small intestine, that catalyses the hydrolysis of sucrose into its components (glucose and fructose). * * * su·crase… …   Medical dictionary Sucrase-Isomaltase — Masse/Länge Primärstruktur 1826 Aminosäuren …   Deutsch Wikipedia Sucrase-isomaltase — protein Name=sucrase isomaltase (alpha glucosidase) caption= width= HGNCid=10856 Symbol=SI AltSymbols= EntrezGene=6476 OMIM=609845 RefSeq=NM 001041 UniProt=P14410 PDB= ECnumber=3.2.1.10 Chromosome=3 Arm=q Band=25.2 LocusSupplementaryData=… …   Wikipedia sucrase-isomaltase complex — the enzyme complex comprising sucrase and α dextrinase (isomaltase) activities, occurring in the brush border of the intestinal mucosa and hydrolyzing maltose as well as maltotriose and some other glycosidic bonds; the enzymes are… …   Medical dictionary sucrase-isomaltase deficiency — a disaccharidase deficiency caused by mutations in the SI gene (locus: 3q25 q26), which encodes the sucrase isomaltase complex of the intestinal mucosa, leading to deficient activity of the complex with resulting malabsorption of sucrose and… …   Medical dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”