Beta-glucosidase

protein
Name=glucosidase, beta; acid (includes glucosylceramidase)
caption=


width=
HGNCid=4177
Symbol=GBA
AltSymbols=GLUC
EntrezGene=2629
OMIM=606463
RefSeq=NM_000157
UniProt=P04062
PDB=
ECnumber=3.2.1.21
Chromosome=1
Arm=q
Band=22
LocusSupplementaryData=protein
Name=glucosidase, beta, acid 3 (cytosolic)
caption=


width=
HGNCid=19069
Symbol=GBA3
AltSymbols=
EntrezGene=57733
OMIM=606619
RefSeq=NM_020973
UniProt=Q9H227
PDB=
ECnumber=3.2.1.21
Chromosome=4
Arm=p
Band=15.31
LocusSupplementaryData=

Beta-glucosidase is a glucosidase enzyme which acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose). An exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.

Cellulose is largely composed of polymers of beta-bond linked glucose molecules, and beta-glucosidases are required by organisms (some fungi, bacteria, termites) that can consume it.

Lysozyme, an enzyme secreted in tears to prevent bacterial infection of the eye, is also a beta-glucosidase that cleaves β1->4 bonds between N-acetylglucosamine and N-acetylmuramic acid sugars within the peptidoglycan cell walls of gram-negative bacteria.

External links

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References

# Nelson DL, Cox MM. "Lehninger: Principles of Biochemistry" 2000 p 306-308
# GO-database listing [http://www.ebi.ac.uk/ego/DisplayGoTerm?id=GO:0016162&selected=GO:0004553&viz=graph 'GO:0016162 cellulose 1,4-beta-cellobiosidase activity']