NEU3

Sialidase 3 (membrane sialidase)
Identifiers
Symbols	NEU3; FLJ12388; SIAL3
External IDs	OMIM: 604617 MGI: 1355305 HomoloGene: 4847 GeneCards: NEU3 Gene
EC number	3.2.1.18
Gene Ontology Molecular function • catalytic activity • exo-alpha-sialidase activity • hydrolase activity, acting on glycosyl bonds • alpha-sialidase activity Cellular component • plasma membrane • integral to plasma membrane Biological process • carbohydrate metabolic process • ganglioside catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10825	50877
Ensembl	ENSG00000162139	ENSMUSG00000035239
UniProt	Q9UQ49	Q543I9
RefSeq (mRNA)	NM_006656	NM_016720.2
RefSeq (protein)	NP_006647	NP_057929.1
Location (UCSC)	Chr 11: 74.7 – 74.73 Mb	Chr 7: 106.96 – 106.98 Mb
PubMed search	[1]	[2]

Sialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.^[1][2]

This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.^[2]

Interactions

NEU3 has been shown to interact with Grb2.^[3]

References

1. ^ Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H, Miyagi T (Aug 1999). "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase". Biochem Biophys Res Commun 261 (1): 21–7. doi:10.1006/bbrc.1999.0973. PMID 10405317. 
2. ^ ^{a b} "Entrez Gene: NEU3 sialidase 3 (membrane sialidase)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10825. 
3. ^ Sasaki, Akinori; Hata Keiko, Suzuki Susumu, Sawada Masashi, Wada Tadashi, Yamaguchi Kazunori, Obinata Masuo, Tateno Hiroo, Suzuki Hiroshi, Miyagi Taeko (Jul. 2003). "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. (United States) 278 (30): 27896–902. doi:10.1074/jbc.M212200200. ISSN 0021-9258. PMID 12730204. 

Further reading

• Hu H, Shioda T, Moriya C et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. PMC 190813. PMID 8892864. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=190813. 
• Monti E, Bassi MT, Papini N et al. (2001). "Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane". Biochem. J. 349 (Pt 1): 343–51. doi:10.1042/0264-6021:3490343. PMC 1221155. PMID 10861246. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221155. 
• Wang Y, Yamaguchi K, Wada T et al. (2002). "A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains". J. Biol. Chem. 277 (29): 26252–9. doi:10.1074/jbc.M110515200. PMID 12011038. 
• Kakugawa Y, Wada T, Yamaguchi K et al. (2002). "Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10718–23. doi:10.1073/pnas.152597199. PMC 125023. PMID 12149448. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125023. 
• Hart ML, Saifuddin M, Uemura K et al. (2003). "High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1". AIDS Res. Hum. Retroviruses 18 (17): 1311–7. doi:10.1089/088922202320886352. PMID 12487819. 
• Oehler C, Kopitz J, Cantz M (2003). "Substrate specificity and inhibitor studies of a membrane-bound ganglioside sialidase isolated from human brain tissue". Biol. Chem. 383 (11): 1735–42. doi:10.1515/BC.2002.194. PMID 12530538. 
• Sasaki A, Hata K, Suzuki S et al. (2003). "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. 278 (30): 27896–902. doi:10.1074/jbc.M212200200. PMID 12730204. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Brandenberger R, Wei H, Zhang S et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
• Ha KT, Lee YC, Cho SH et al. (2004). "Molecular characterization of membrane type and ganglioside-specific sialidase (Neu3) expressed in E. coli". Mol. Cells 17 (2): 267–73. PMID 15179041. 
• Stamatos NM, Liang F, Nan X et al. (2005). "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages". FEBS J. 272 (10): 2545–56. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103. 
• Kato K, Shiga K, Yamaguchi K et al. (2006). "Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling". Biochem. J. 394 (Pt 3): 647–56. doi:10.1042/BJ20050737. PMC 1383714. PMID 16241905. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1383714. 
• Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Ueno S, Saito S, Wada T et al. (2006). "Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility". J. Biol. Chem. 281 (12): 7756–64. doi:10.1074/jbc.M509668200. PMID 16428383. 
• Yamaguchi K, Hata K, Wada T et al. (2006). "Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles". Biochem. Biophys. Res. Commun. 346 (2): 484–90. doi:10.1016/j.bbrc.2006.05.136. PMID 16765317. 
• Nan X, Carubelli I, Stamatos NM (2007). "Sialidase expression in activated human T lymphocytes influences production of IFN-gamma". J. Leukoc. Biol. 81 (1): 284–96. doi:10.1189/jlb.1105692. PMID 17028199. 
• Yoshizumi S, Suzuki S, Hirai M et al. (2007). "Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice". Metab. Clin. Exp. 56 (3): 420–9. doi:10.1016/j.metabol.2006.10.027. PMID 17292733. 
• Wada T, Hata K, Yamaguchi K et al. (2007). "A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells". Oncogene 26 (17): 2483–90. doi:10.1038/sj.onc.1210341. PMID 17334392. 
• Azuma Y, Sato H, Higai K, Matsumoto K (2007). "Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis". Biol. Pharm. Bull. 30 (9): 1680–4. doi:10.1248/bpb.30.1680. PMID 17827720.