NEU4

Sialidase 4
Identifiers
Symbols	NEU4; FLJ35928; MGC102757; MGC18222
External IDs	OMIM: 608527 MGI: 2661364 HomoloGene: 15433 GeneCards: NEU4 Gene
EC number	3.2.1.18
Gene Ontology Molecular function • exo-alpha-sialidase activity • protein binding • hydrolase activity, acting on glycosyl bonds Cellular component • mitochondrion • lysosome • lysosome • membrane • organelle inner membrane • lysosomal lumen Biological process • metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	129807	241159
Ensembl	ENSG00000204099	ENSMUSG00000034000
UniProt	Q8WWR8	Q6NS66
RefSeq (mRNA)	NM_001167599.1	NM_173772.3
RefSeq (protein)	NP_001161071.1	NP_776133.1
Location (UCSC)	Chr 2: 242.75 – 242.76 Mb	Chr 1: 95.92 – 95.92 Mb
PubMed search	[1]	[2]

Sialidase-4 is an enzyme that in humans is encoded by the NEU4 gene.^[1]

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.^[1]

Interactions

NEU4 has been shown to interact with PLSCR1.^[2]

References

1. ^ ^{a b} "Entrez Gene: NEU4 sialidase 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=129807. 
2. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Comelli EM, Amado M, Lustig SR, Paulson JC (2004). "Identification and expression of Neu4, a novel murine sialidase.". Gene 321: 155–61. doi:10.1016/j.gene.2003.08.005. PMID 14637003. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Monti E, Bassi MT, Bresciani R, et al. (2004). "Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family.". Genomics 83 (3): 445–53. doi:10.1016/j.ygeno.2003.08.019. PMID 14962670. 
• Seyrantepe V, Landry K, Trudel S, et al. (2004). "Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells.". J. Biol. Chem. 279 (35): 37021–9. doi:10.1074/jbc.M404531200. PMID 15213228. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524842. 
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
• Stamatos NM, Liang F, Nan X, et al. (2005). "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages.". FEBS J. 272 (10): 2545–56. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.