Ménétrier's disease

Ménétrier's disease
Ménétrier's disease
Classification and external resources

Ménétrier's disease. In this case, there was so much pit hyperplasia that the giant folds appeared to be covered by a myriad of polyps resembling hyperplastic polyps. The muscularis propria is the folded structure at the bottom center.
ICD-10 K29.6
ICD-9 535.2
OMIM 137280
DiseasesDB 8001
MeSH D005758

Ménétrier disease (also known as hyperplastic hypersecretory gastropathy, and named after a French physician Pierre Eugène Ménétrier, 1859–1935), a disorder in which the gastric mucosal folds (rugae) are enlarged[1] (and the total weight of the stomach is increased), making the surface of the stomach look a bit like the brain gyri. This leads to protein loss, parietal cell atrophy, and an increase in mucous cells. It results from profound hyperplasia of the surface mucous cells with accompanying glandular atrophy.



The altered gastric mucosa secretes massive amounts of mucus, resulting in low plasma protein levels. The tissue may be inflamed and may contain ulcers. The disease also causes glands in the stomach to waste away and causes the body to lose fluid containing the protein albumin.There are two forms of the disease: a childhood form and an adult form. The childhood form has a better prognosis. It affects males three times more than females, most often after they have a viral illness caused by cytomegalovirus (CMV) or a bacterial infection caused by Helicobacter pylori. Children are not born with this disease, and it is not passed from parents to their children.[2] The adult form is linked with overexpression of transforming growth factor alpha (TGF-α). The adult variety is four times more common in men, primarily affecting men between ages 30 and 60.


The presenting symptoms are:

Ménétrier disease increases a person's risk of stomach cancer.[3] Microscopically, the disease is characterized by hyperplasia of the crypts, which are elongated and may appear cystic or corkscrew-like.

Since it predisposes to stomach cancer, periodic endoscopic surveillance is mandated. CMV-related Ménétrier is often self-limited.


Ménétrier's disease seen at CT, coronal reconstruction. There is also a liver cyst.

The disease maybe diagnosed by x-ray or endoscopy and biopsy of the stomach.


In adults, there is no FDA approved treatment other than gastrectomy and a high-protein diet. Part or all of the stomach may need to be removed if the disease is severe. However, the monoclonal antibody cetuximab has been used in compassionate use for treatment of Ménétrier's disease[4] .

Pediatric cases are normally treated for symptoms with the disease clearing up in weeks to months.

Related conditions

Other forms of hyperplastic gastropathy include Zollinger-Ellison syndrome.


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Look at other dictionaries:

  • Ménétrier's disease — a disorder in which gross enlargement (see hypertrophy) of the cells of the mucous membrane lining the stomach is associated with anaemia. P. Ménétrier (1859 1935), French physician …   Medical dictionary

  • Ménétrier's disease — a disorder in which gross enlargement (see hypertrophy) of the cells of the mucous membrane lining the stomach is associated with anaemia [Ménétrier (1859–1935), French physician] …   The new mediacal dictionary

  • Disease, Menetrier — A premalignant disorder of the stomach characterized by overgrowth of the stomach lining (gastric mucosa), nausea and vomiting and abdominal pain, and hypoalbuminemia (low blood serum level of albumin) due to loss of albumin by the stomach. The… …   Medical dictionary

  • Ménétrier-Syndrom — Klassifikation nach ICD 10 K29.6 Sonstige Gastritis …   Deutsch Wikipedia

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  • Ménétrier — Pierre E., French physician, 1859–1935. See M. disease, M. syndrome …   Medical dictionary

  • Pierre Eugène Ménétrier — (1859 1935) was a French pathologist from Paris. He is remembered for his description of a rare gastric disorder that was later to become known as Ménétrier s disease. In 1888 Ménétrier first described this disorder while performing post mortem… …   Wikipedia

  • Digestive disease — Classification and external resources MeSH D004066 All diseases that pertain to the gastrointestinal tract are labelled as digestive diseases. This includes diseases of the esophagus, stomach, first, second, and third part of the …   Wikipedia

  • Enfermedad de Menetrier — Saltar a navegación, búsqueda La enfermedad de Ménétrier, también conocida como gastropatía hipersecretoria hiperplásica y gastropatía hipertrófica perdedora de proteínas, es un trastorno de la mucosa del estómago en la que se corruga, se… …   Wikipedia Español

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