Zollinger-Ellison syndrome

Zollinger-Ellison syndrome

Infobox_Disease
Name = PAGENAME


Caption = Endoscopy image of multiple small ulcers in the distal duodenum in a patient with Zollinger-Ellison syndrome
DiseasesDB =
ICD10 = ICD10|E|16|4|e|15
ICD9 = ICD9|251.5
ICDO =
OMIM =
MedlinePlus = 000325
eMedicineSubj = med
eMedicineTopic = 2437
eMedicine_mult = eMedicine2|ped|2472 | MeshID = D015043

Zollinger-Ellison syndrome is a disorder where increased levels of the hormone gastrin are produced, causing the stomach to produce excess hydrochloric acid. Often the cause is a tumor (gastrinoma) of the duodenum or pancreas producing the hormone gastrin. Gastrin then causes an excessive production of acid which can lead to peptic ulcers (in almost 95% of patients)

Gastrin works on stomach parietal cells causing them to secrete more hydrogen ions into the stomach lumen. In addition, gastrin acts as a trophic factor for parietal cells, causing parietal cell hyperplasia. Thus there is an increase in the number of acid-secreting cells, and each of these cells produces acid at a higher rate. The increase in acidity contributes to the development of peptic ulcers in the stomach and duodenum.High acid levels lead to multiple ulcers in the stomach and small bowel.

Patients with Zollinger-Ellison syndrome may experience abdominal pain and diarrhea. The diagnosis is also suspected in patients without symptoms who have severe ulceration of the stomach and small bowel, especially if they fail to respond to treatment.

Gastrinomas may occur as single tumors or as multiple, small tumors. About one-half to two-thirds of single gastrinomas are malignant tumors that most commonly spread to the liver and lymph nodes near the pancreas and small bowel. Nearly 25 percent of patients with gastrinomas have multiple tumors as part of a condition called multiple endocrine neoplasia type I (MEN I). MEN I patients have tumors in their pituitary gland and parathyroid glands in addition to tumors of the pancreas.

ymptoms

*epigastric pain (stomachache)
*vomiting blood (hematemesis) (occasional)
*difficulty in eating
*diarrhea
*steatorrhea

Diagnosis

The diagnosis of Zollinger-Ellison syndrome is made by several laboratory tests and imaging studies.

Laboratory tests:
* secretin stimulation test, which measures gastrin levels in response to secretin
* fasting gastrin levels
* antral acidity

Therapy

Proton pump inhibitors (such as omeprazole and lansoprazole) and histamine H2-receptor antagonists (such as famotidine and ranitidine) are used to slow down acid secretion. If possible the tumours should be surgically removed, or treated with chemotherapy.

Octreotide can be used to slow down acid secretion.

History

This syndrome was first described in 1955 by R Zollinger and E Ellison.cite journal |author=Zollinger RM, Ellison EH |title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas |journal=Ann. Surg. |volume=142 |issue=4 |pages=709–23; discussion, 724–8 |year=1955 |pmid=13259432|doi=10.1097/00000658-195510000-00015]

Footnotes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • ZOLLINGER-ELLISON (SYNDROME DE) — ZOLLINGER ELLISON SYNDROME DE Le syndrome de Zollinger Ellison est une affection endocrinienne caractérisée par une hyperproduction de gastrine du fait d’une tumeur (plus souvent maligne que bénigne) ou d’une hyperplasie endocrine siégeant le… …   Encyclopédie Universelle

  • Zollinger-Ellison syndrome — A rare disorder caused by a tumor called a gastrinoma, most often occurring in the pancreas. The tumor secretes the hormone gastrin, which causes increased production of gastric acid leading to severe recurrent ulcers of the esophagus, stomach,… …   Medical dictionary

  • Zollinger-Ellison syndrome — noun syndrome consisting of intractable peptic ulceration with gastric hypersecretion and hyperacidity • Hypernyms: ↑syndrome * * * ¦zäliŋər¦elə̇sən noun Usage: usually capitalized Z&E Etymology: after Robert M. Zollinger died 1992 and Edwin H.… …   Useful english dictionary

  • Zollinger-Ellison syndrome — /zol ing euhr el euh seuhn/, Pathol. a condition in which a gastrin secreting tumor of the pancreas or small intestine causes excessive secretion of gastric juice, leading to intractable peptic ulcers. [after Robert Milton Zollinger (born 1903)… …   Universalium

  • Zollinger-Ellison syndrome — a rare disorder in which there is excessive secretion of gastric juice due to high levels of circulating gastrin, which is produced by a pancreatic tumour (see gastrinoma) or an enlarged pancreas. The high levels of stomach acid cause diarrhoea… …   The new mediacal dictionary

  • Zollinger-Ellison syndrome — noun A disorder where increased levels of the hormone gastrin are produced, causing the stomach to produce excess hydrochloric acid; often caused by a tumor (gastrinoma) of the duodenum or pancreas, and resulting in peptic ulcers …   Wiktionary

  • Zollinger-Ellison syndrome — A disorder in which tumors of the pancreatic islet cells produce large amounts of gastrin (a hormone), leading to excess acid in the stomach and, possibly, a peptic ulcer (ulcer of the stomach or the upper part of the small intestine) …   English dictionary of cancer terms

  • Zollinger - Ellison syndrome — …   Useful english dictionary

  • Zollinger–Ellison syndrome — …   Useful english dictionary

  • Zollinger-Ellison-Syndrom — Klassifikation nach ICD 10 E16.4 Abnorme Gastrinsekretion Zollinger Ellison Syndrom …   Deutsch Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”