Monobactam

Aztreonam. (The square is the β-lactam. There is a second thiazole ring, but it is not fused to the β-lactam ring.)

Tigemonam

Monobactams are β-lactam compounds wherein the β-lactam ring is alone and not fused to another ring (in contrast to most other β-lactams, which have at least two rings). They work only against Gram-negative bacteria.^{[citation needed]}

The only commercially available monobactam antibiotic is aztreonam.

Other examples of monobactams are tigemonam,^[1] nocardicin A, and tabtoxin.

Adverse effects to monobactams can include skin rash and occasional abnormal liver functions.

They have no cross-hypersensitivity reactions with penicillin.

References

1. ^ Fuchs PC, Jones RN, Barry AL (March 1988). "In vitro antimicrobial activity of tigemonam, a new orally administered monobactam". Antimicrob. Agents Chemother. 32 (3): 346–9. PMC 172173. PMID 3259122. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=3259122. 

External links

• MeSH Monobactams

This systemic antibacterial-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Beta-lactam antibiotics Antibiotic stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Ammonium dihydrogen phosphate Monobia quadridens Look at other dictionaries: Monobactam — Monobactame (beispielsweise Aztreonam) sind Antibiotika, die von gramnegativen Bakterien produziert und synthetisch modifiziert werden. Sie enthalten nur noch einen monozyklischen β Lactam Ring. Sie sind β Lactamase stabil, werden jedoch aus dem… …   Deutsch Wikipedia monobactam — noun Any of various beta lactam compounds wherein the beta lactam ring is alone, not fused to another ring …   Wiktionary monobactam — A class of antibiotic that has a monocyclic β lactam nucleus and is structurally different from other β lactams; e.g., aztreonam. * * * mono·bac·tam .män ō bak tam n any of the class of beta lactam antibiotics (as aztreonam) with a monocyclic… …   Medical dictionary Monobactam — Mo|no|bac|tam [vermutlich Kurzw. aus monocyclisch u. Beta Lactam], das; s, e: Gruppenbez. für aus Bakterien isolierte oder synthetisierte Azetidinonsulfonsäure Derivate, die antibiotisch wirksam sind …   Universal-Lexikon Aztreonam — Systematic (IUPAC) name 2 ({[(1Z …   Wikipedia Tigemonam — IUPAC name 2 [[1 (2 Amino 1,3 thiazol 4 yl) 2 [[(3S) 2,2 dimethyl 4 oxo 1 sulfooxyazetidin 3 yl]amino] 2 oxoethylidene]amino]oxyacetic …   Wikipedia Beta-lactamase — Beta lactamases are enzymes (EC number|3.5.2.6) produced by some bacteria and are responsible for their resistance to beta lactam antibiotics like penicillins, cephalosporins, cephamycins, ertapenems and carbapenems. These antibiotics have a… …   Wikipedia Beta-lactam antibiotic — β lactam antibiotics are a broad class of antibiotics that include penicillin derivatives, cephalosporins, monobactams, carbapenems, and β lactamase inhibitors, that is, any antibiotic agent that contains a β lactam nucleus in its molecular… …   Wikipedia aztreonam — A synthetic bactericidal monolactam antibiotic with a wide spectrum of activity against Gram negative aerobic pathogens. * * * az·tre·o·nam .az trē ō .nam, az trē n a synthetic monobactam antibiotic C13H17N5O8S2 used esp. against gram negative… …   Medical dictionary Bactericide — A bactericide or bacteriocide is a substance that kills bacteria and, preferably, nothing else. Bactericides are either disinfectants, antiseptics or antibiotics. Important Functional Groups in a Bactericidal Substance The most used bactericidal… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”