- Map44
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mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) Identifiers Symbol MASP1 Alt. symbols CRARF, PRSS5 Entrez 5648 HUGO 6901 OMIM 600521 RefSeq NM_001879 UniProt P48740 Other data Locus Chr. 3 q27-q28 Mannose-binding lectin-associated protein of 44 kDa (MAp44) is a protein arising from the human MASP1 gene. MASP-1, MASP-3 and MAp44 are alternative splice products of the MASP1 gene. MAp44 has been suggested to act as a competitive inhibitor of lectin pathway activation, by displacing MASP-2 from MBL, hence preventing cleavage of C4 and C2 [1]
See also
- mannan-binding lectin
- lectin pathway
References
- ^ Degn, Søren; Annette G. Hansen, Rudi Steffensen,Christian Jacobsen, Jens C. Jensenius and Steffen Thiel (November 2009). "MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation". Journal of Immunology 183 (11): 7371–7378. doi:10.4049/jimmunol.0902388. PMID 19917686. http://www.jimmunol.org/cgi/content/full/183/11/7371.
External links
Proteins: complement system (C, L, A) Activators/enzymes EarlyMiddleLateInhibitors Complement receptors Digestive enzymes Coagulation factors: Thrombin · Factor VIIa · Factor IXa · Factor Xa · Factor XIa · Factor XIIa · Kallikrein (PSA, KLK1, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK12, KLK13, KLK14, KLK15)
fibrinolysis: Plasmin · Plasminogen activator (Tissue plasminogen activator · Urinary plasminogen activator)Complement system Other immune system Venombin Other Acrosin · Prolyl endopeptidase · Pronase · Proprotein convertases (1, 2) · Reelin · Subtilisin/Furin · Streptokinase · S1P · Cathepsin (A, G)Categories:- Genes on chromosome 3
- Complement system
- Chromosome 3 gene stubs
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