Germinoma Classification and external resources
Micrograph of a germinoma. H&E stain.
ICD-O: 9060-9061, M9064/3 MeSH D018237
The term germinoma most often has referred to a tumor in the brain that has a histology identical to two other tumors: dysgerminoma in the ovary and seminoma in the testis. Since 1994, MeSH has defined germinoma as "a malignant neoplasm of the germinal tissue of the gonads; mediastinum; or pineal region" and within its scope included both dysgerminoma and seminoma. Collectively, these are the seminomatous or germinomatous tumors.
Germinomas are thought to originate from an error of development, when certain primordial germ cells fail to migrate properly. Germinomas lack histologic differentiation, whereas nongerminomatous germ cell tumors display a variety of differentiation. Like other germ cell tumors, germinomas can undergo malignant transformation.
On gross examination, the external surface is smooth and bosselated (knobby), and the interior is soft, fleshy and either cream-coloured, gray, pink or tan. Microscopic examination typically reveals uniform cells that resemble primordial germ cells. Typically, the stroma contains lymphocytes and about 20% of patients have sarcoid-like granulomas.
Metastasis has been noted in approximately 22% of cases at time of diagnosis. Males are approximately twice as commonly affected in developing germinomas. Germinomas are most commonly diagnosed between the age of 10 and 21.
Often serum and spinal fluid tumor markers of AFP and beta-HCG are tested. Pure germinomas are not associated with these markers. Nongerminomatous germ cell tumors may be associated with increased markers such as AFP with yolk sac tumors as well as embryonic cell carcinomas and immature teratomas and beta-HCG which occur in choriocarcinomas. In 1-15% of germinonas a low level of beta-HCG may be produced. Although controversial, there are some thoughts that HCG-secreting germinomas are more aggressive than nonsecreting ones.
Ovary (dysgerminoma) and testis (seminoma)
Dysgerminoma is the most common type of malignant germ cell ovarian cancer. Dysgerminoma usually occurs in adolescence and early adult life; about 5% occur in pre-pubertal children. Dysgerminoma is extremely rare after age 50. Dysgerminoma occurs in both ovaries in 10% of patients and, in a further 10%, there is microscopic tumor in the other ovary.
Abnormal gonads (due to gonadal dysgenesis and androgen insensitivity syndrome) have a high risk of developing a dysgerminoma. Most dysgerminomas are associated with elevated serum lactic dehydrogenase (LDH), which is sometimes used as a tumor marker.
Metastases are most often present in the lymph nodes.
Intracranial germinoma occurs in 0.7 per million children. As with other germ cell tumors (GCTs) occurring outside the gonads, the most common location of intracranial germinoma is on or near the midline, often in the pineal or suprasellar areas; in 5-10% of patients with germinoma in either area, the tumor is in both areas. Like other (GCTs), germinomas can occur in other areas of the brain. Within the brain, this tumor is most common in the hypothalamic or hypophyseal regions. In the thalamus and basal ganglia, germinoma is the most common GCT.
The diagnosis of an intracranial germinoma usually is based on biopsy, because the features on neuroimaging are similar to other tumors.
Intracranial germinomas have a reported 90% survival to five years after diagnosis. Near total resection does not seem to influence the cure rate, so gross total resection is not necessary and can increase the risk of complications from surgery. The best results have been reported from craniospinal radiation with local tumor boost of greater than 4,000 cGy.
Treatment and prognosis
Germinomas, like several other types of germ cell tumor, are sensitive to both chemotherapy and radiotherapy. For this reason, with treatment patients' chances of long term survival, even cure, is excellent.
Although chemotherapy can shrink germinomas, it is not generally recommended alone unless there are contraindications to radiation possibly based on a study in the early 1990s where carboplatinum, etoposide and bleomycin were given to 45 germinoma patients. About half the patients relapsed. Most of these relapsed patients were recovered with radiation or additional chemotherapy.
- Brown-Sequard Syndrome (sections on Cavernous malformation and Germinoma)
- Spermatocytic seminomatemodal (treatment)
- ^ "Germinoma" at Dorland's Medical Dictionary
- ^ Germinoma, Central Nervous System at eMedicine
- ^ "Pathology". http://www.med-ed.virginia.edu/courses/path/gyn/ovary3.cfm. Retrieved 2007-11-03.
- ^ MeSH Germinoma
- ^ Sadler, T.W. 2006. Langman's medical Embryology, 10th Edition, Chapter 15, pp. 251-252. Lippincott, Williams & Wilkins, Pub.
- ^ Keene D, Johnston D, Strother D et al. (2007). "Epidemiological survey of central nervous system germ cell tumors in Canadian children". J. Neurooncol. 82 (3): 289–95. doi:10.1007/s11060-006-9282-2. PMID 17120159.
- ^ Packer RJ, Cohen BH, Cooney K, Coney K (2000). "Intracranial germ cell tumors". Oncologist 5 (4): 312–20. PMID 10964999. http://theoncologist.alphamedpress.org/cgi/content/full/5/4/312#R9.
- ^ Ueba T, Yamashita K, Fujisawa I et al. (2007). "Long-term follow-up of 5 patients with intracranial germinoma initially treated by chemotherapy alone". Acta neurochirurgica 149 (9): 897–902; discussion 902. doi:10.1007/s00701-007-1268-0. PMID 17690837.
- ^ Balmaceda C, Heller G, Rosenblum M et al. (1996). "Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study". J. Clin. Oncol. 14 (11): 2908–15. PMID 8918487.
Germ cell tumors (ICD-O 9060–9119) (C45–C49/D17–D21, 171/214–215) GerminomatousGerminoma (Seminoma, Dysgerminoma) Nongerminomatous Tumors: female urogenital neoplasia (C51–C58/D25–D28, 179–184/218–221) AdnexaGlandular and epithelial/
stromal tumorSex cord-gonadal stromal
UterusGeneral Vagina Vulva Tumor markers BloodLymphosarcoma Endocrine Nervous system Cardiovascular/
General histology Musculoskeletal
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