TMPRSS2

Transmembrane protease, serine 2, also known as TMPRSS2, is a human gene.cite web | title = Entrez Gene: TMPRSS2 transmembrane protease, serine 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7113| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. The biological function of this gene is unknown.cite web | title = Entrez Gene: TMPRSS2 transmembrane protease, serine 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7113| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Paoloni-Giacobino A, Chen H, Peitsch MC, "et al." |title=Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. |journal=Genomics |volume=44 |issue= 3 |pages= 309–20 |year= 1997 |pmid= 9325052 |doi= 10.1006/geno.1997.4845
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Lin B, Ferguson C, White JT, "et al." |title=Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. |journal=Cancer Res. |volume=59 |issue= 17 |pages= 4180–4 |year= 1999 |pmid= 10485450 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Vaarala MH, Porvari KS, Kellokumpu S, "et al." |title=Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues. |journal=J. Pathol. |volume=193 |issue= 1 |pages= 134–40 |year= 2001 |pmid= 11169526 |doi= 10.1002/1096-9896(2000)9999:9999<::AID-PATH743>3.0.CO;2-T |doilabel=10.1002/1096-9896(2000)9999:9999::AID-PATH7433.0.CO;2-T
*cite journal | author=Afar DE, Vivanco I, Hubert RS, "et al." |title=Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. |journal=Cancer Res. |volume=61 |issue= 4 |pages= 1686–92 |year= 2001 |pmid= 11245484 |doi=
*cite journal | author=Jacquinet E, Rao NV, Rao GV, "et al." |title=Cloning and characterization of the cDNA and gene for human epitheliasin. |journal=Eur. J. Biochem. |volume=268 |issue= 9 |pages= 2687–99 |year= 2001 |pmid= 11322890 |doi=
*cite journal | author=Teng DH, Chen Y, Lian L, "et al." |title=Mutation analyses of 268 candidate genes in human tumor cell lines. |journal=Genomics |volume=74 |issue= 3 |pages= 352–64 |year= 2001 |pmid= 11414763 |doi= 10.1006/geno.2001.6551
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wilson S, Greer B, Hooper J, "et al." |title=The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells. |journal=Biochem. J. |volume=388 |issue= Pt 3 |pages= 967–72 |year= 2005 |pmid= 15537383 |doi= 10.1042/BJ20041066
*cite journal | author=Soller MJ, Isaksson M, Elfving P, "et al." |title=Confirmation of the high frequency of the TMPRSS2/ERG fusion gene in prostate cancer. |journal=Genes Chromosomes Cancer |volume=45 |issue= 7 |pages= 717–9 |year= 2006 |pmid= 16575875 |doi= 10.1002/gcc.20329
*cite journal | author=Tomlins SA, Mehra R, Rhodes DR, "et al." |title=TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. |journal=Cancer Res. |volume=66 |issue= 7 |pages= 3396–400 |year= 2006 |pmid= 16585160 |doi= 10.1158/0008-5472.CAN-06-0168
*cite journal | author=Yoshimoto M, Joshua AM, Chilton-Macneill S, "et al." |title=Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement. |journal=Neoplasia |volume=8 |issue= 6 |pages= 465–9 |year= 2006 |pmid= 16820092 |doi= 10.1593/neo.06283
*cite journal | author=Böttcher E, Matrosovich T, Beyerle M, "et al." |title=Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. |journal=J. Virol. |volume=80 |issue= 19 |pages= 9896–8 |year= 2006 |pmid= 16973594 |doi= 10.1128/JVI.01118-06
*cite journal | author=Cerveira N, Ribeiro FR, Peixoto A, "et al." |title=TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions. |journal=Neoplasia |volume=8 |issue= 10 |pages= 826–32 |year= 2006 |pmid= 17032499 |doi= 10.1593/neo.06427
*cite journal | author=Yoo NJ, Lee JW, Lee SH |title=Absence of fusion of TMPRSS2 and ETS transcription factor genes in gastric and colorectal carcinomas. |journal=APMIS |volume=115 |issue= 3 |pages= 252–3 |year= 2007 |pmid= 17367471 |doi= 10.1111/j.1600-0463.2007.apm_652.x
*cite journal | author=Winnes M, Lissbrant E, Damber JE, Stenman G |title=Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer. |journal=Oncol. Rep. |volume=17 |issue= 5 |pages= 1033–6 |year= 2007 |pmid= 17390040 |doi=
*cite journal | author=Tu JJ, Rohan S, Kao J, "et al." |title=Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues. |journal=Mod. Pathol. |volume=20 |issue= 9 |pages= 921–8 |year= 2007 |pmid= 17632455 |doi= 10.1038/modpathol.3800903

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