SPINK1

SPINK1

Serine peptidase inhibitor, Kazal type 1, also known as SPINK1, is a human gene.cite web | title = Entrez Gene: SPINK1 serine peptidase inhibitor, Kazal type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6690| accessdate = ]

It has been associated with prostate cancer.cite journal |author=Tomlins SA, Rhodes DR, Yu J, "et al" |title=The role of SPINK1 in ETS rearrangement-negative prostate cancers |journal=Cancer Cell |volume=13 |issue=6 |pages=519–28 |year=2008 |month=June |pmid=18538735 |doi=10.1016/j.ccr.2008.04.016 |url=http://linkinghub.elsevier.com/retrieve/pii/S1535-6108(08)00152-9]

ee also

* Pancreatitis

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References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Marchbank T, Freeman TC, Playford RJ |title=Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair. |journal=Digestion |volume=59 |issue= 3 |pages= 167–74 |year= 1998 |pmid= 9643675 |doi=
*cite journal | author=Pfützer RH, Whitcomb DC |title=SPINK1 mutations are associated with multiple phenotypes. |journal=Pancreatology |volume=1 |issue= 5 |pages= 457–60 |year= 2002 |pmid= 12120224 |doi=
*cite journal | author=Schneider A |title=Serine protease inhibitor kazal type 1 mutations and pancreatitis. |journal=Clin. Lab. Med. |volume=25 |issue= 1 |pages= 61–78 |year= 2005 |pmid= 15749232 |doi= 10.1016/j.cll.2004.12.005
*cite journal | author=Cohn JA, Mitchell RM, Jowell PS |title=The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis. |journal=Clin. Lab. Med. |volume=25 |issue= 1 |pages= 79–100 |year= 2005 |pmid= 15749233 |doi= 10.1016/j.cll.2004.12.007
*cite journal | author=Kandula L, Whitcomb DC, Lowe ME |title=Genetic issues in pediatric pancreatitis. |journal=Current gastroenterology reports |volume=8 |issue= 3 |pages= 248–53 |year= 2006 |pmid= 16764792 |doi=
*cite journal | author=Bartelt DC, Shapanka R, Greene LJ |title=The primary structure of the human pancreatic secretory trypsin inhibitor. Amino acid sequence of the reduced S-aminoethylated protein. |journal=Arch. Biochem. Biophys. |volume=179 |issue= 1 |pages= 189–99 |year= 1977 |pmid= 843082 |doi=
*cite journal | author=Hecht HJ, Szardenings M, Collins J, Schomburg D |title=Three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (Kazal type). |journal=J. Mol. Biol. |volume=225 |issue= 4 |pages= 1095–103 |year= 1992 |pmid= 1613792 |doi=
*cite journal | author=Hecht HJ, Szardenings M, Collins J, Schomburg D |title=Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type). |journal=J. Mol. Biol. |volume=220 |issue= 3 |pages= 711–22 |year= 1991 |pmid= 1870127 |doi=
*cite journal | author=Freeman TC, Davies R, Calam J |title=Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: its hydrolysis and protection by intraluminal factors. |journal=Clin. Chim. Acta |volume=195 |issue= 1-2 |pages= 27–39 |year= 1991 |pmid= 2093478 |doi=
*cite journal | author=Kido H, Yokogoshi Y, Katunuma N |title=A low-molecular-mass Kazal-type protease inhibitor isolated from rat hepatocytes is identical to rat pancreatic secretory trypsin inhibitor II. Purification and amino acid sequence. |journal=Eur. J. Biochem. |volume=188 |issue= 3 |pages= 501–6 |year= 1990 |pmid= 2110056 |doi=
*cite journal | author=Tomita N, Horii A, Yamamoto T, "et al." |title=Expression of pancreatic secretory trypsin inhibitor gene in neoplastic tissues. |journal=FEBS Lett. |volume=225 |issue= 1-2 |pages= 113–9 |year= 1988 |pmid= 2961612 |doi=
*cite journal | author=Horii A, Kobayashi T, Tomita N, "et al." |title=Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene. |journal=Biochem. Biophys. Res. Commun. |volume=149 |issue= 2 |pages= 635–41 |year= 1988 |pmid= 3501289 |doi=
*cite journal | author=Yamamoto T, Nakamura Y, Nishide J, "et al." |title=Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA. |journal=Biochem. Biophys. Res. Commun. |volume=132 |issue= 2 |pages= 605–12 |year= 1985 |pmid= 3877508 |doi=
*cite journal | author=Huhtala ML, Pesonen K, Kalkkinen N, Stenman UH |title=Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer. |journal=J. Biol. Chem. |volume=257 |issue= 22 |pages= 13713–6 |year= 1983 |pmid= 7142173 |doi=
*cite journal | author=Klaus W, Schomburg D |title=Solution structure of a variant of human pancreatic secretory trypsin inhibitor determined by nuclear magnetic resonance spectroscopy. |journal=J. Mol. Biol. |volume=229 |issue= 3 |pages= 695–706 |year= 1993 |pmid= 8433367 |doi= 10.1006/jmbi.1993.1073
*cite journal | author=Chen JM, Mercier B, Audrezet MP, Ferec C |title=Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis. |journal=J. Med. Genet. |volume=37 |issue= 1 |pages= 67–9 |year= 2000 |pmid= 10691414 |doi=
*cite journal | author=Witt H, Luck W, Hennies HC, "et al." |title=Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. |journal=Nat. Genet. |volume=25 |issue= 2 |pages= 213–6 |year= 2000 |pmid= 10835640 |doi= 10.1038/76088
*cite journal | author=Pfützer RH, Barmada MM, Brunskill AP, "et al." |title=SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. |journal=Gastroenterology |volume=119 |issue= 3 |pages= 615–23 |year= 2000 |pmid= 10982753 |doi=
*cite journal | author=Kaneko K, Nagasaki Y, Furukawa T, "et al." |title=Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis. |journal=J. Hum. Genet. |volume=46 |issue= 5 |pages= 293–7 |year= 2001 |pmid= 11355022 |doi=

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