mir-BHRF1-3 microRNA precursor family

mir-BHRF1-3 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-BHRF1-3
Identifiers
Symbol	mir-BHRF1-3
Rfam	RF00367
Other data
RNA type	Gene; miRNA
Domain(s)	Viruses
GO	0035195 0035068
SO	0001244

The mir-BHRF1-3 microRNA precursor found in Human herpesvirus 4 (Epstein-Barr virus). In Epstein-Barr virus, mir-BHRF1-3 is found in the 3' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 5' arm of the hairpin.^[1] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-1 and Mir-BHRF1-2.^[1]

BHRF-1-3 miRNA is though to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein-Barr virus genome.^[2] BHRF-3 has been shown to be expressed in latency-III infected lymphoblasts.^[3]

References

1. ^ ^{a b} Pfeffer, S; Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T (2004). "Identification of Virus-Encoded MicroRNAs". Science 304 (5671): 734–736. doi:10.1126/science.1096781. PMID 15118162. 
2. ^ Feederle, R; Haar, J, Bernhardt, K, Linnstaedt, SD, Bannert, H, Lips, H, Cullen, BR, Delecluse, HJ (2011 Jul 13). "The members of a viral miRNA cluster co-operate to transform B lymphocytes.". Journal of virology. PMID 21752900. 
3. ^ Xing, L; Kieff, E (2007 Sep). "Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication.". Journal of virology 81 (18): 9967–75. PMID 17626073. 

External links

• Rfam page for mir-BHRF1-3 microRNA precursor family