Mir-196 microRNA precursor family

miR-196 is a non-coding RNA called a microRNA that has been shown to be expressed in human ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000238 MI0000238] , [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000279 MI0000279] ) and mouse ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000552 MI0000552] , [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000553 MI0000553] ) [1,2] . miR-196 appears to be a vertebrate specific microRNA and has now been predicted or experimentally confirmed in a wide range of vertebrate species ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000031 MIPF0000031] ). In many species the miRNA appears to be expressed from intergenic regions in HOX gene clusters. The hairpin precursors are predicted based on base pairing and cross-species conservation -- their extents are not known. In this case the mature sequence is excised from the 5' arm of the hairpin.

References

* [1] cite journal | last = Lagos-Quintana | first = M | coauthors = Rauhut R, Meyer J, Borkhardt A, Tuschl T | year = 2003 | title = New microRNAs from mouse and human | journal = RNA | volume = 9 | pages = 175–179 | pmid = 12554859 | doi = 10.1261/rna.2146903
* [2] cite journal | last = Lim | first = LP | coauthors = Glasner ME, Yekta S, Burge CB, Bartel DP | year = 2003 | title = Vertebrate microRNA genes | journal = Science | volume = 299 | pages = 1540– | pmid = 12624257 | doi = 10.1126/science.1080372

External links

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000031 MIPF0000031]