Mir-199 microRNA precursor

The miR-199 microRNA precursor (homologous to miR-215), is a short non-coding RNAgene involved in gene regulation. miR-192 and miR-215 have now been predicted or experimentally confirmed in mouse and humancite journal |author=Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T |title=New microRNAs from mouse and human |journal=RNA |volume=9 |issue=2 |pages=175–9 |year=2003 |pmid=12554859 |doi=] cite journal |author=Houbaviy HB, Murray MF, Sharp PA |title=Embryonic stem cell-specific MicroRNAs |journal=Dev. Cell |volume=5 |issue=2 |pages=351–8 |year=2003 |pmid=12919684 |doi=] cite journal |author=Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G |title=Numerous microRNPs in neuronal cells containing novel microRNAs |journal=RNA |volume=9 |issue=2 |pages=180–6 |year=2003 |pmid=12554860 |doi=] ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000040 MIPF0000040] ).
microRNAs are transcribed as ~70 nucleotideprecursors and subsequently processed by the Dicer enzyme to givea ~22 nucleotide product. The mature products are thought to haveregulatory roles through complementarity to mRNA cite journal |author=Ambros V |title=microRNAs: tiny regulators with great potential |journal=Cell |volume=107 |issue=7 |pages=823–6 |year=2001 |pmid=11779458 |doi=] .

References

External links

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000040 miRBase family MIPF0000040]