mir-2 microRNA precursor

mir-2 microRNA precursor
Predicted secondary structure and sequence conservation of mir-2
Identifiers
Symbol	mir-2
Rfam	RF00047
miRBase	MI0000117
miRBase family	MIPF0000049
Other data
RNA type	Gene; miRNA
Domain(s)	Eukaryota
GO	0035195 0035068
SO	0001244

This family represents the microRNA (miRNA) precursors mir-2 and mir-13 (MIPF0000049). Genomic loci encoding miR-2 products have been described in a wide range of species and these products have been experimentally verified in multiple invertebrates. The miRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The products are thought to have regulatory roles through complementarity to mRNA. The involvement of Dicer in miRNA processing suggests a relationship with the phenomenon of RNA interference. MicroRNAs are numbered based on the mature sequence. This family also contains the mir-13 precursor which, despite giving rise to a distinct mature sequence appears to be related in sequence.

By specific antisense-mediated inactivation of miR-2 products, Boutla et al. first demonstrated a fundamental role of mir-2 family during development.^[1] Leaman et al.. showed that the miR-2 family regulates cell survival by translational repression of proapoptotic factors ^[2]

References

1. ^ Boutla, A; Delidakis, C; Tabler, M (2003). "Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes". Nucleic Acids Research 31 (17): 4973-4980. doi:10.1093/nar/gkg707. PMID 12930946. 
2. ^ Leaman, D; Chen PY, Fak J, Yalcin A, Pearce M, Unnerstall U, Marks DS, Sander C, Tuschl T, Gaul U (2005). "Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development". Cell 121 (7): 1097–1108. doi:10.1016/j.cell.2005.04.016. PMID 15989958. 

External links

• Rfam page for mir-2 microRNA precursor
• MIPF0000049