Mir-15 microRNA precursor family

The miR-15 microRNA precursor family are small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences. In humans miR-15a and miR-16 are clustered within 0.5 kilobases at 13q14. [cite journal | last = Lagos-Quintana | first = M | coauthors = Rauhut R, Lendeckel W, Tuschl T | year = 2001 | title = Identification of novel genes coding for small expressed RNAs | journal = Science | volume = 294 | pages = 853–858 | pmid = 11679670 | doi = 10.1126/science.1064921] This region has been shown to be deleted in more than half of B cell chronic lymphocytic leukaemias (CLL). Both miR-15a and miR-16 are deleted or down-regulated in more than two thirds of CLL cases. [cite journal | last = Calin | first = GA | coauthors = Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM | year = 2002 | title = Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia | journal = Proc Natl Acad Sci U S A | volume = 99 | pages = 15524–15529 | pmid = 12434020 | doi = 10.1073/pnas.242606799] The mature sequence is excised from the 5' arm of the hairpin.

References

External links

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000069 miRBase entry MI0000069]
* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000438 miRBase entryMI0000438]