mir-15 microRNA precursor family

mir-15 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-15
Identifiers
Symbol	mir-15
Rfam	RF00455
miRBase	MI0000069
miRBase family	MIPF0000006
Other data
RNA type	Gene; miRNA
Domain(s)	Eukaryota
GO	0035195 0035068
SO	0001244

The miR-15 microRNA precursor family are small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences. In humans miR-15a and miR-16 are clustered within 0.5 kilobases at 13q14.^[1] This region has been shown to be deleted in more than half of B-cell chronic lymphocytic leukemias (CLL). Both miR-15a and miR-16 are deleted or down-regulated in more than two thirds of CLL cases.^[2] The mature sequence is excised from the 5' arm of the hairpin. In mouse lymphoid development, the miR-15 family has been implicated in turning down cell cycle by down-regulation of check-point genes.^[3]

References

1. ^ Lagos-Quintana, M; Rauhut R, Lendeckel W, Tuschl T (2001). "Identification of novel genes coding for small expressed RNAs". Science 294 (5543): 853–858. doi:10.1126/science.1064921. PMID 11679670. 
2. ^ Calin, GA; Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM (2002). "Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia". Proc Natl Acad Sci USA 99 (24): 15524–15529. doi:10.1073/pnas.242606799. PMC 137750. PMID 12434020. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137750. 
3. ^ Costa, IG; Roepcke S., Schliep, A- (2007). "Gene expression trees in lymphoid development". BMC Immunology 8: 25. doi:10.1186/1471-2172-8-25. PMC 2244641. PMID 17925013. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2244641. 

Further reading

• Finnerty JR, Wang WX, Hébert SS, Wilfred BR, Mao G, Nelson PT (August 2010). "The miR-15/107 Group of MicroRNA Genes: Evolutionary Biology, Cellular Functions, and Roles in Human Diseases". J Mol Biol 402 (3): 491–509. doi:10.1016/j.jmb.2010.07.051. PMC 2978331. PMID 20678503. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2978331. 
• Cimmino A, Calin GA, Fabbri M, et al. (September 2005). "miR-15 and miR-16 induce apoptosis by targeting BCL2". Proc. Natl. Acad. Sci. U.S.A. 102 (39): 13944–9. doi:10.1073/pnas.0506654102. PMC 1236577. PMID 16166262. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1236577. 
• Palamarchuk A, Efanov A, Nazaryan N, et al. (May 2010). "13q14 deletions in CLL involve cooperating tumor suppressors". Blood 115 (19): 3916–22. doi:10.1182/blood-2009-10-249367. PMC 2869560. PMID 20071661. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2869560. 
• Aqeilan RI, Calin GA, Croce CM (February 2010). "miR-15a and miR-16-1 in cancer: discovery, function and future perspectives". Cell Death Differ. 17 (2): 215–20. doi:10.1038/cdd.2009.69. PMID 19498445. 
• Guo CJ, Pan Q, Li DG, Sun H, Liu BW (April 2009). "miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis". J. Hepatol. 50 (4): 766–78. doi:10.1016/j.jhep.2008.11.025. PMID 19232449. 
• Xia L, Zhang D, Du R, et al. (July 2008). "miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells". Int. J. Cancer 123 (2): 372–9. doi:10.1002/ijc.23501. PMID 18449891. 

External links

• Rfam page for mir-15 microRNA precursor family
• miRBase entry MI0000069
• miRBase entryMI0000438