Mir-130 microRNA precursor family

In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000156 MI0000156] , [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000408 MI0000408] ), [cite journal | last = Lagos-Quintana | first = M | coauthors = Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T | year = 2002 | title = Identification of tissue-specific microRNAs from mouse | journal = Curr Biol | volume = 12 | pages = 735–739 | pmid = 12007417 | doi = 10.1016/S0960-9822(02)00809-6] and in human ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000448 MI0000448] , [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000748 MI0000748] ). [cite journal | last = Houbaviy | first = HB | coauthors = Murray MF, Sharp PA | year = 2003 | title = Embryonic stem cell-specific MicroRNAs | journal = Dev Cell | volume = 5 | pages = 351–358 | pmid = 12919684 | doi = 10.1016/S1534-5807(03)00227-2] miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000034 MIPF0000034] ). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma.cite journal | author = Kutay H, Bai S, Datta J, "et al" | title = Downregulation of miR-122 in the rodent and human hepatocellular carcinomas | journal = J. Cell. Biochem. | volume = 99 | issue = 3 | pages = 671–8 | year = 2006 | pmid = 16924677 | doi = 10.1002/jcb.20982 | issn = ]

References

External links

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000034 miRBase family MIPF0000034]