- mir-130 microRNA precursor family
-
mir-130 microRNA precursor family 
Predicted secondary structure and sequence conservation of mir-130 Identifiers Symbol mir-130 Rfam RF00258 miRBase MI0000448 miRBase family MIPF0000034 Other data RNA type Gene; miRNA Domain(s) Eukaryota GO 0035195 0035068 SO 0001244 In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408),[1] and in human (MI0000448, MI0000748).[2] miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma.[3]
References
- ^ Lagos-Quintana, M; Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
- ^ Houbaviy, HB; Murray MF, Sharp PA (2003). "Embryonic stem cell-specific MicroRNAs". Dev Cell 5 (2): 351–358. doi:10.1016/S1534-5807(03)00227-2. PMID 12919684.
- ^ Kutay H, Bai S, Datta J, et al. (2006). "Downregulation of miR-122 in the rodent and human hepatocellular carcinomas". J. Cell. Biochem. 99 (3): 671–8. doi:10.1002/jcb.20982. PMC 3033198. PMID 16924677. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3033198.
External links
miRNA precursor families 1-100 101-200 201+ Other Categories:- MicroRNA
- Molecular and cellular biology stubs
Wikimedia Foundation. 2010.
