Mir-135 microRNA precursor family

The miR-135 microRNA precursor is a small non-coding RNA that is involved in regulating gene expression. It has been shown to be expressed in human, mouse and rat. [cite journal | last = Lagos-Quintana | first = M | coauthors = Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T | year = 2002 | title = Identification of tissue-specific microRNAs from mouse | journal = Curr Biol | volume = 12 | pages = 735–739 | pmid = 12007417 | doi = 10.1016/S0960-9822(02)00809-6] [cite journal | last = Kim | first = J | coauthors = Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G | year = 2004 | title = Identification of many microRNAs that copurify with polyribosomes in mammalian neurons | journal = Proc Natl Acad Sci U S A | volume = 101 | pages = 360–365 | pmid = 14691248 | doi = 10.1073/pnas.2333854100] miR-135 has now been predicted or experimentally confirmed in a wide range of vertebrate species ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000028 MIPF0000028] ). Precursor microRNAs are ~70 nucleotides in length and are processed by the Dicer enzyme to produce the shorter 21-24 nucleotide mature sequence. In this case the mature sequence is excised from the 5' arm of the hairpin.

References

External links

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000028 MIPF0000028]