- mir-135 microRNA precursor family
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mir-135 microRNA precursor family 
Predicted secondary structure and sequence conservation of mir-135 Identifiers Symbol mir-135 Rfam RF00246 miRBase MI0000452 miRBase family MIPF0000028 Other data RNA type Gene; miRNA Domain(s) Eukaryota GO 0035195 0035068 SO 0001244 The miR-135 microRNA precursor is a small non-coding RNA that is involved in regulating gene expression. It has been shown to be expressed in human, mouse and rat.[1][2] miR-135 has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000028). Precursor microRNAs are ~70 nucleotides in length and are processed by the Dicer enzyme to produce the shorter 21-24 nucleotide mature sequence. In this case the mature sequence is excised from the 5' arm of the hairpin.
Targets of miR-135
- Nagel et al.. showed that miR-135a and b target the 3' untranslated region of the APC gene.[3]
References
- ^ Lagos-Quintana, M; Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
- ^ Kim, J; Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G (2004). "Identification of many microRNAs that copurify with polyribosomes in mammalian neurons". Proc Natl Acad Sci USA 101 (1): 360–365. Bibcode 2003PNAS..101..360K. doi:10.1073/pnas.2333854100. PMC 314190. PMID 14691248. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=314190.
- ^ Nagel R, le Sage C, Diosdado B, et al (July 2008). "Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer". Cancer research 68 (14): 5795–802. doi:10.1158/0008-5472.CAN-08-0951. PMID 18632633.
External links
miRNA precursor families 1-100 101-200 201+ Other Categories:- MicroRNA
- Molecular and cellular biology stubs
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