Mir-219 microRNA precursor family

In molecular biology, the microRNA miR-219 was predicted in vertebrates by conservation between human, mouse and pufferfish and cloned in pufferfish. [cite journal | last = Lim | first = LP | coauthors = Glasner ME, Yekta S, Burge CB, Bartel DP | year = 2003 | title = Vertebrate microRNA genes | journal = Science | volume = 299 | pages = 1540– | pmid = 12624257 | doi = 10.1126/science.1080372] It was later predicted and confirmed experimentally in Drosophila. [cite journal | last = Lai | first = EC | coauthors = Tomancak P, Williams RW, Rubin GM | year = 2003 | title = Computational identification of Drosophila microRNA genes | journal = Genome Biol | volume = 4 | pages = R42– | pmid = 12844358 | doi = 10.1186/gb-2003-4-7-r42] Homologs of miR-219 have since been predicted or experimentally confirmed in a wide range of species, including the platyhelminth Schmidtea mediterranea, several arthropod species and a wide range of vertebrates ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000044 MIPF0000044] ). The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 5' arm of the hairpin.

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000044 MIPF0000044]