mir-19 microRNA precursor family

mir-19 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-19
Identifiers
Symbol	mir-19
Rfam	RF00245
miRBase	MI0000073
miRBase family	MIPF0000011
Other data
RNA type	Gene; miRNA
Domain(s)	Eukaryota
GO	0035195 0035068
SO	0001244

The miR-19 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. Within the human and mouse genome there are three copies of this microRNA that are processed from multiple predicted precursor hairpins:^{[1][2] [3]}

• mouse (MI0000546, MI0000688, MI0000718)
• human (MI0000073, MI0000074, and MI000075).

miR-19 has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000011). In this case the mature sequence is excised from the 3' arm of the hairpin precursor.

Targets of miR-19

It has been shown that the 3' UTR of the ATXN1 gene contains 3 target sites for miR-19, and that this microRNA shows moderate down regulation of reporter genes containing the ATXN1 3' UTR. ATXN1 is also regulated by miR-101, and miR-130.^[4]

References

1. ^ Lagos-Quintana, M; Rauhut R, Lendeckel W, Tuschl T (2001). "Identification of novel genes coding for small expressed RNAs". Science 294 (5543): 853–858. doi:10.1126/science.1064921. PMID 11679670. 
2. ^ Mourelatos, Z; Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev 16 (6): 720–728. doi:10.1101/gad.974702. PMC 155365. PMID 11914277. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=155365. 
3. ^ Houbaviy, HB; Murray MF, Sharp PA (2003). "Embryonic stem cell-specific MicroRNAs". Dev Cell 5 (2): 351–358. doi:10.1016/S1534-5807(03)00227-2. PMID 12919684. 
4. ^ Lee Y, Samaco RC, Gatchel JR, Thaller C, Orr HT, Zoghbi HY (October 2008). "miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis". Nat. Neurosci. 11 (10): 1137–9. doi:10.1038/nn.2183. PMC 2574629. PMID 18758459. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2574629. 

External links

• Rfam page for mir-19 microRNA precursor family
• miRBase family entry for miR-19 family