- miR-144
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miR-144 
Conserved secondary structure of miR-144 precursor microRNA Identifiers Symbol miR-144 Alt. Symbols MIR144 Rfam RF00682 miRBase MI0000460 miRBase family MIPF0000093 Entrez 406936 HUGO 31531 OMIM 612070 RefSeq NR_029685 Other data RNA type miRNA Domain(s) Mammalia GO 0035195 SO 0001244 Locus Chr. 17 q11.2 miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precusor hairpin by the enzyme Dicer.[1] In humans, miR-144 has been characterised as a "common miRNA signature"[2] of a number of different tumours.
GATA4 is thought to activate transcription of the miR-144 microRNA precursor.[3]
Function
miR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis.[4] One of the identified targets of miR-144 is insulin receptor substrate 1.[5]
Applications
miR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder.[6] It has also been suggested as a potential therapeutic tool to treat ischemic heart disease.[3]
References
- ^ Ambros, V (2001 Dec 28). "microRNAs: tiny regulators with great potential.". Cell 107 (7): 823–6. PMID 11779458.
- ^ Wang, W; Peng, B, Wang, D, Ma, X, Jiang, D, Zhao, J, Yu, L (2011 Oct 1). "Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets.". International journal of cancer. Journal international du cancer 129 (7): 1624–34. PMID 21128228.
- ^ a b Zhang, X; Wang, X, Zhu, H, Zhu, C, Wang, Y, Pu, WT, Jegga, AG, Fan, GC (2010 Nov). "Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death.". Journal of molecular and cellular cardiology 49 (5): 841–50. PMID 20708014.
- ^ Rasmussen, KD; Simmini, S, Abreu-Goodger, C, Bartonicek, N, Di Giacomo, M, Bilbao-Cortes, D, Horos, R, Von Lindern, M, Enright, AJ, O'Carroll, D (2010 Jul 5). "The miR-144/451 locus is required for erythroid homeostasis.". The Journal of experimental medicine 207 (7): 1351–8. PMID 20513743.
- ^ Karolina, DS; Armugam, A, Tavintharan, S, Wong, MT, Lim, SC, Sum, CF, Jeyaseelan, K (2011). "MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus.". PloS one 6 (8): e22839. PMID 21829658.
- ^ Dinan, TG (2010 Apr). "MicroRNAs as a target for novel antipsychotics: a systematic review of an emerging field.". The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 13 (3): 395–404. PMID 19849891.(subscription required)
Further reading
- Zhang, HY; Zheng, SJ, Zhao, JH, Zhao, W, Zheng, LF, Zhao, D, Li, JM, Zhang, XF, Chen, ZB, Yi, XN (2011 Apr 6). "MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection.". Brain research 1383: 62–70. PMID 21276775.
External links
miRNA precursor families 1-100 101-200 201+ Other Categories:- Genes on chromosome 17
- MicroRNA
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