Mir-16 microRNA precursor family

The miR-16 microRNA precursor family is a group of related small non-coding RNA genes that regulate gene expression. miR-16, miR-15, mir-195 and miR-457 are related microRNA precursor sequences ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF000006 MIPF000006] ). This microRNA family appears to be vertebrate specific and members of this family have been predicted or experimentally validated in a wide range of vertebrate species ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000006 MIPF0000006] ). miR-16 and miR-15a are clustered within 0.5 kilobases at 13q14 in human, a chromosomal region shown to be deleted or down-regulated in more than half of B cell chronic lymphocytic leukaemias (CLL). [cite journal | last = Calin | first = GA | coauthors = Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM | year = 2002 | title = Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia | journal = Proc Natl Acad Sci U S A | volume = 99 | pages = 15524–15529 | pmid = 12434020 | doi = 10.1073/pnas.242606799]

References

External links

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000006 miRBase family MIPF0000006]