Mir-46/mir-47/mir-281 microRNA precursor family

In molecular biology, mir-46 ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000017 MI0000017] ) and mir-47 ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000018 MI0000018] ) are microRNA expressed in "C. elegans" from related hairpin precursor sequences. [cite journal | last = Lau | first = NC | coauthors = Lim LP, Weinstein EG, Bartel DP | year = 2001 | title = An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans | journal = Science | volume = 294 | pages = 858–862 | pmid = 11679671 | doi = 10.1126/science.1065062] The predicted hairpin precursor sequences for "Drosophila" mir-281 ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000366 MI0000366] , [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000370 MI0000370] ) [cite journal | last = Lai | first = EC | coauthors = Tomancak P, Williams RW, Rubin GM | year = 2003 | title = Computational identification of Drosophila microRNA genes | journal = Genome Biol | volume = 4 | pages = R42– | pmid = 12844358 | doi = 10.1186/gb-2003-4-7-r42] [cite journal | last = Aravin | first = AA | coauthors = Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T | year = 2003 | title = The small RNA profile during Drosophila melanogaster development | journal = Dev Cell | volume = 5 | pages = 337–350 | pmid = 12919683 | doi = 10.1016/S1534-5807(03)00228-4] are also related and, hence, belong to this family. The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequences are expressed from the 3' arms of the hairpin precursors.

References

External links

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000017 MI0000017]
* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000018 MI0000018]
* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000366 MI0000366]
* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000370 MI0000370]