mir-8/mir-141/mir-200 microRNA precursor family

mir-8/mir-141/mir-200 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-8
Identifiers
Symbol	mir-8
Rfam	RF00241
miRBase	MI0000128
miRBase family	MIPF0000019
Other data
RNA type	Gene; miRNA
Domain(s)	Eukaryota
GO	0035195 0035068
SO	0001244

The miR-8 microRNA precursor (homologous to miR-141, miR-200, miR-236), is a short non-coding RNA gene involved in gene regulation. miR-8 from Drosophila ^[1] (MI0000128), human and mouse miR-141 (MI0000166, MI0000457), miR-429 (MI0001642), miR-200 (MI0000243, MI0000342) ^[2] and miR-236 ([1])are expressed from the 3' arm of related precursor hairpins (represented here). Members of this precursor family have now been predicted or experimentally confirmed in a wide range of species (MIPF0000019). The bounds of the precursors are predicted based on conservation and base pairing and are not generally known.

Targets of miR-8

The atrophin gene has been shown to be a target of drosophila miR-8.^[3] It has also been suggested that this target is also conserved in mammalian miR-8.

The human miR-200c is likely to target the zinc finger transcription factor transcription factor 8 (TCF8) gene.^[4]

References

1. ^ Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T (2001). "Identification of novel genes coding for small expressed RNAs". Science 294 (5543): 853–8. doi:10.1126/science.1064921. PMID 11679670. 
2. ^ Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T (2003). "New microRNAs from mouse and human". RNA 9 (2): 175–9. doi:10.1261/rna.2146903. PMC 1370382. PMID 12554859. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370382. 
3. ^ Karres JS, Hilgers V, Carrera I, Treisman J, Cohen SM (2007). "The Conserved microRNA MiR-8 Tunes Atrophin Levels to Prevent Neurodegeneration in Drosophila". Cell 131 (1): 136–45. doi:10.1016/j.cell.2007.09.020. PMID 17923093. 
4. ^ Hurteau GJ, Carlson JA, Spivack SD, Brock GJ (2007). "Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin". Cancer Res. 67 (17): 7972–6. doi:10.1158/0008-5472.CAN-07-1058. PMID 17804704. 

External links

• Rfam page for mir-8/mir-141/mir-200 microRNA precursor family