Mir-BART2 microRNA precursor family

The mir-BART2 microRNA precursor found in Human herpesvirus 4 (Epstein-Barr virus) and Cercopithicine herpesvirus 15. mir-BART2 is expressed in all stages of infection but expression is significantly elevated in the lytic stage. In Epstein-Barr virus, mir-BART2 is found in the intronic regions of the BART (Bam HI-A region rightward transcript) gene whose function is unknown. mir-BART2 is thought to target the virally encoded DNA polymerase BALF5 for degradation. The mature sequence is excised from the 5' arm of the hairpin. [cite journal | last = Pfeffer | first = S | coauthors = Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T | year = 2004 | title = Identification of Virus-Encoded MicroRNAs | journal = Science | volume = 304 | pages = 734–736 | pmid = 15118162 | doi = 10.1126/science.1096781]

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