Mir-10 microRNA precursor family

The miR-10 microRNA precursor, is a short non-coding RNA gene involved in gene regulation. It is also part of an RNA gene family which contains miR-10, miR-51, miR-57, miR-99 and miR-100. miR-10, miR-99 and miR-100 have now been predicted or experimentally confirmed in a wide range of species [cite journal | last = Lee | first = RC | coauthors = Ambros V | year = 2001 | title = An extensive class of small RNAs in Caenorhabditis elegans | journal = Science | volume = 294 | pages = 862–864 | pmid = 11679672 | doi = 10.1126/science.1065329] [cite journal | last = Ambros | first = V | year = 2001 | title = microRNAs: tiny regulators with great potential | journal = Cell | volume = 107 | pages = 823–826 | pmid = 11779458 | doi = 10.1016/S0092-8674(01)00616-X] ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000033 MIPF0000033] , [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000025 MIPF0000025] ). mir-51 and mir-57 have currently only been identified in the nematode "Caenorhabditis elegans" ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000268 MIPF0000268] , [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000271 MIPF0000271] ). microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.

References

External links

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000033 miRBase family MIPF0000033]
* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000025 miRBase family MIPF0000025]
* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000268 miRBase family MIPF0000268]
* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000271 miRBase family MIPF0000271]