Mir-124 microRNA precursor family

The miR-124 microRNA precursor is a small non-coding RNA molecule that has been identified in flies ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000373 MI0000373] ), [cite journal | last = Lai | first = EC | coauthors = Tomancak P, Williams RW, Rubin GM | year = 2003 | title = Computational identification of Drosophila microRNA genes | journal = Genome Biol | volume = 4 | pages = R42– | pmid = 12844358 | doi = 10.1186/gb-2003-4-7-r42] nematode worms ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000302 MI0000302] ), [cite journal | last = Lim | first = LP | coauthors = Lau NC, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, Burge CB, Bartel DP | year = 2003 | title = The microRNAs of Caenorhabditis elegans | journal = Genes Dev | volume = 17 | pages = 991–1008 | pmid = 12672692 | doi = 10.1101/gad.1074403] mouse ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000150 MI0000150] ) and human ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000443 MI0000443] ). [cite journal | last = Lagos-Quintana | first = M | coauthors = Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T | year = 2002 | title = Identification of tissue-specific microRNAs from mouse | journal = Curr Biol | volume = 12 | pages = 735–739 | pmid = 12007417 | doi = 10.1016/S0960-9822(02)00809-6] The mature ~21 nucleotide microRNAs are processed from hairpin precursor sequences by the Dicer enzyme, and in this case originates from the 3' arm. miR-124 has been found to be the most abundant microRNA expressed in neuronal cells. Experiments to alter expression of miR-124 in neural cells did not appear to affect differentiation.cite journal | author = Cao X, Pfaff SL, Gage FH | title = A functional study of miR-124 in the developing neural tube | journal = Genes Dev. | volume = 21 | issue = 5 | pages = 531–6 | year = 2007 | pmid = 17344415 | doi = 10.1101/gad.1519207 ]

Targets of miR-124

* Visvanathan "et al". showed that miR-124 targets the mRNA of the anti-neural function protein SCP1 (small C-terminal domain phosphatase 1).cite journal | author = Visvanathan J, Lee S, Lee B, Lee JW, Lee SK | title = The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development | journal = Genes Dev. | volume = 21 | issue = 7 | pages = 744–9 | year = 2007 | pmid = 17403776 | doi = 10.1101/gad.1519107 ]

References

External links

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000021 miRBase family for miR-124]