Mir-156 microRNA precursor

This family represents the plant microRNA (miRNA) precursor mir-156. This miRNA has now been predicted or experimentally confirmed in a range of plant species ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000008 MIPF0000008] ). Animal miRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In plants the precursor sequences may be longer, and the carpel factory (caf) enzyme appears to be involved in processing. In this case the mature sequence comes from the 5' arm of the precursor, and both Arabidopsis and rice genomes contain a number of related miRNA precursors which give rise to almost identical mature sequences. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The products are thought to have regulatory roles through complementarity to mRNA.

References

* [1] cite journal | last = Reinhart | first = BJ | coauthors = Weinstein EG, Rhoades MW, Bartel B, Bartel DP | year = 2002 | title = MicroRNAs in plants | journal = Genes Dev | volume = 16 | pages = 1616–1626 | pmid = 12101121 | doi = 10.1101/gad.1004402
* [2] cite journal | last = Ambros | first = V | year = 2001 | title = microRNAs: tiny regulators with great potential | journal = Cell | volume = 107 | pages = 823–826 | pmid = 11779458 | doi = 10.1016/S0092-8674(01)00616-X

External links

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000008 MIPF0000008]